Cdk13 cyclin dependent kinase 13 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdk13provided by MGI
Official Full Name: cyclin dependent kinase 13provided by MGI
Primary source: MGI:MGI:1916812
See related: Ensembl:ENSMUSG00000041297 AllianceGenome:MGI:1916812
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cdc2l5; 2310015O17Rik
Summary: Enables cyclin binding activity and protein kinase binding activity. Involved in alternative mRNA splicing, via spliceosome. Acts upstream of or within negative regulation of stem cell differentiation. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Is expressed in several structures, including brain; future brain; primitive streak; trophectoderm; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in congenital heart defects, dysmorphic facial features, and intellectual developmental disorder. Orthologous to human CDK13 (cyclin dependent kinase 13). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 9.0), thymus adult (RPKM 8.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A2; 13 6.05 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (17885309..17979960, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (17711676..17805212, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
Title: Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer.
The findings of this study suggest that Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.
Title: Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139622 (e-PCR)
- UniSTS:221706

CDC2L5_3913 (e-PCR)
- UniSTS:462093

BB440067 (e-PCR)
- UniSTS:208893

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	ISO Inferred from Sequence Orthology more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
involved_in alternative mRNA splicing, via spliceosome	IDA Inferred from Direct Assay more info	PubMed
involved_in hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
part_of cyclin K-CDK13 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin/CDK positive transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of nuclear cyclin-dependent protein kinase holoenzyme complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-dependent kinase 13

Names: CDC2-related protein kinase 5; cell division cycle 2-like 5 (cholinesterase-related cell division controller); cell division cycle 2-like protein kinase 5; cell division protein kinase 13

NP_001074527.1

EC 2.7.11.22

EC 2.7.11.23

NP_081394.1

EC 2.7.11.22

EC 2.7.11.23

XP_006516829.1

EC 2.7.11.22

EC 2.7.11.23

XP_006516830.1

EC 2.7.11.22

EC 2.7.11.23

XP_011242646.1

EC 2.7.11.22

EC 2.7.11.23

XP_017171082.1

EC 2.7.11.22

EC 2.7.11.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081058.2 → NP_001074527.1 cyclin-dependent kinase 13 isoform 1

See identical proteins and their annotated locations for NP_001074527.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC154219, AC154828

Consensus CDS

CCDS36604.1

UniProtKB/Swiss-Prot

E9QKZ6, Q69ZA1, Q80V11, Q8BZG1, Q8K0A4

Related

ENSMUSP00000036013.8, ENSMUST00000042365.9

Conserved Domains (2) summary

smart00220
Location:705 → 994

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:697 → 998

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
NM_027118.1 → NP_081394.1 cyclin-dependent kinase 13 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.

Source sequence(s)

AC154219, AC154828

Consensus CDS

CCDS88417.1

UniProtKB/Swiss-Prot

Q69ZA1

Related

ENSMUSP00000152820.2, ENSMUST00000223490.2

Conserved Domains (2) summary

smart00220
Location:705 → 994

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd07864
Location:697 → 998

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

17885309..17979960 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006516767.5 → XP_006516830.1 cyclin-dependent kinase 13 isoform X2

Conserved Domains (1) summary

cd07864
Location:697 → 998

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_006516766.5 → XP_006516829.1 cyclin-dependent kinase 13 isoform X1

Conserved Domains (1) summary

cd07864
Location:697 → 998

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_011244344.4 → XP_011242646.1 cyclin-dependent kinase 13 isoform X4

UniProtKB/TrEMBL

A0A1Y7VLM0

Related

ENSMUSP00000152539.2, ENSMUST00000222800.2

Conserved Domains (1) summary

cd07864
Location:83 → 384

STKc_CDK12; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12
XM_017315593.3 → XP_017171082.1 cyclin-dependent kinase 13 isoform X3

Conserved Domains (1) summary

cl21453
Location:697 → 929

PKc_like; Protein Kinases, catalytic domain