Loxl2 lysyl oxidase-like 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Loxl2provided by RGD
Official Full Name: lysyl oxidase-like 2provided by RGD
Primary source: RGD:1308435
See related: Ensembl:ENSRNOG00000016758 AllianceGenome:RGD:1308435
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable metal ion binding activity; oligosaccharide binding activity; and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; peptidyl-lysine oxidation; and positive regulation of cell differentiation. Located in basement membrane. Orthologous to human LOXL2 (lysyl oxidase like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 138.7), Kidney (RPKM 138.2) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15p11

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (51091547..51182843)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (44683449..44773067)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (51276022..51365238)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LOXL2 attenuates osteoarthritis through inactivating Integrin/FAK signaling.
Title: LOXL2 attenuates osteoarthritis through inactivating Integrin/FAK signaling.
Dual inhibition of LOXL2 and LOXL3 in a pulmonary fibrosis model was sufficient to normalize collagen fibrillogenesis, reduce tissue stiffness, and improve lung function in vivo.
Title: Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.

Submit: New GeneRIF Correction

General gene information

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Markers

D15Mgh11 (e-PCR), detects polymorphism
- UniSTS:226669

D15Wox4 (e-PCR)
- UniSTS:519024

RH124140 (e-PCR)
- UniSTS:161004

D15Arb7 (e-PCR)
- UniSTS:239343

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables copper ion binding	ISO Inferred from Sequence Orthology more info
enables copper ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables oligosaccharide binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info
enables oligosaccharide binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein-lysine 6-oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-lysine 6-oxidase activity	IEA Inferred from Electronic Annotation more info
enables protein-lysine 6-oxidase activity	ISO Inferred from Sequence Orthology more info
enables protein-lysine 6-oxidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in collagen fibril organization	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in endothelial cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in heterochromatin organization	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin organization	ISO Inferred from Sequence Orthology more info
involved_in heterochromatin organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of stem cell population maintenance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in peptidyl-lysine oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chondrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial to mesenchymal transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein modification process	IEA Inferred from Electronic Annotation more info
involved_in protein modification process	ISO Inferred from Sequence Orthology more info
involved_in protein modification process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to copper ion	IEA Inferred from Electronic Annotation more info
involved_in response to copper ion	ISO Inferred from Sequence Orthology more info
involved_in response to copper ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in sprouting angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in sprouting angiogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
part_of chromatin	IEA Inferred from Electronic Annotation more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: lysyl oxidase homolog 2

Names: lysyl oxidase-like protein 2

NP_001099517.2

EC 1.4.3.13

XP_038949076.1

EC 1.4.3.13

XP_038949077.1

EC 1.4.3.13

XP_038949078.2

EC 1.4.3.13

XP_038949079.1

EC 1.4.3.13

XP_038949080.1

EC 1.4.3.13

XP_038949081.1

EC 1.4.3.13

XP_038949082.2

EC 1.4.3.13

XP_038949083.1

EC 1.4.3.13

XP_063130208.1

EC 1.4.3.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106047.2 → NP_001099517.2 lysyl oxidase homolog 2 precursor

See identical proteins and their annotated locations for NP_001099517.2

Status: PROVISIONAL

Source sequence(s)

BC168900

UniProtKB/Swiss-Prot

B5DF27, F1LPM2

UniProtKB/TrEMBL

A0A0G2K4P0

Related

ENSRNOP00000073118.2, ENSRNOT00000085237.2

Conserved Domains (3) summary

smart00202
Location:61 → 162

SR; Scavenger receptor Cys-rich

pfam00530
Location:70 → 162

SRCR; Scavenger receptor cysteine-rich domain

pfam01186
Location:550 → 745

Lysyl_oxidase; Lysyl oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

51091547..51182843

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093155.2 → XP_038949083.1 lysyl oxidase homolog 2 isoform X6

UniProtKB/Swiss-Prot

B5DF27, F1LPM2

Conserved Domains (2) summary

smart00202
Location:73 → 174

SR; Scavenger receptor Cys-rich

pfam01186
Location:563 → 762

Lysyl_oxidase; Lysyl oxidase
XM_039093153.2 → XP_038949081.1 lysyl oxidase homolog 2 isoform X4

UniProtKB/Swiss-Prot

B5DF27, F1LPM2

Conserved Domains (2) summary

smart00202
Location:61 → 162

SR; Scavenger receptor Cys-rich

pfam01186
Location:586 → 785

Lysyl_oxidase; Lysyl oxidase
XM_039093148.2 → XP_038949076.1 lysyl oxidase homolog 2 isoform X1

UniProtKB/Swiss-Prot

B5DF27, F1LPM2

Conserved Domains (2) summary

smart00202
Location:73 → 174

SR; Scavenger receptor Cys-rich

pfam01186
Location:598 → 797

Lysyl_oxidase; Lysyl oxidase
XM_039093149.2 → XP_038949077.1 lysyl oxidase homolog 2 isoform X2

UniProtKB/Swiss-Prot

B5DF27, F1LPM2

Conserved Domains (2) summary

smart00202
Location:73 → 174

SR; Scavenger receptor Cys-rich

pfam01186
Location:597 → 796

Lysyl_oxidase; Lysyl oxidase
XM_039093154.2 → XP_038949082.2 lysyl oxidase homolog 2 isoform X5
XM_039093150.2 → XP_038949078.2 lysyl oxidase homolog 2 isoform X3
XM_063274138.1 → XP_063130208.1 lysyl oxidase homolog 2 isoform X7

UniProtKB/TrEMBL

A0A0G2K4P0
XM_039093152.2 → XP_038949080.1 lysyl oxidase homolog 2 isoform X4

UniProtKB/Swiss-Prot

B5DF27, F1LPM2

Conserved Domains (2) summary

smart00202
Location:61 → 162

SR; Scavenger receptor Cys-rich

pfam01186
Location:586 → 785

Lysyl_oxidase; Lysyl oxidase
XM_039093151.2 → XP_038949079.1 lysyl oxidase homolog 2 isoform X4

UniProtKB/Swiss-Prot

B5DF27, F1LPM2

Conserved Domains (2) summary

smart00202
Location:61 → 162

SR; Scavenger receptor Cys-rich

pfam01186
Location:586 → 785

Lysyl_oxidase; Lysyl oxidase