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    Cenpk centromere protein K [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294712, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Cenpkprovided by RGD
    Official Full Name
    centromere protein Kprovided by RGD
    Primary source
    RGD:1310461
    See related
    Ensembl:ENSRNOG00000039740 AllianceGenome:RGD:1310461
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Solt
    Summary
    Predicted to be involved in mitotic sister chromatid segregation. Predicted to act upstream of or within positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human CENPK (centromere protein K). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 50.9), Spleen (RPKM 46.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (37094163..37155158)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (35360390..35421372)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (34312766..34373945)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene trafficking protein particle complex subunit 13 Neighboring gene shieldin complex subunit 3 Neighboring gene tripartite motif-containing 23 Neighboring gene peptidylprolyl isomerase domain and WD repeat containing 1 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 6 Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis. Yamashita A, et al. FEBS Lett, 2000 Sep 15. PMID 10996314
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in kinetochore assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of inner kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    centromere protein K
    Names
    SoxLZ/Sox6 leucine zipper binding protein in testis

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399198.1 → NP_001386127.1  centromere protein K isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      A6I5F7
      Related
      ENSRNOP00000081169.1, ENSRNOT00000103473.1
      Conserved Domains (1) summary
      pfam11802
      Location:11 → 267
      CENP-K; Centromere-associated protein K

    2. NM_001399199.1 → NP_001386128.1  centromere protein K isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000002
      Conserved Domains (1) summary
      pfam11802
      Location:11 → 266
      CENP-K; Centromere-associated protein K

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      37094163..37155158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760667.4 → XP_008758889.1  centromere protein K isoform X2

      Conserved Domains (1) summary
      pfam11802
      Location:11 → 216
      CENP-K; Centromere-associated protein K

    2. XM_006231889.5 → XP_006231951.1  centromere protein K isoform X1

      See identical proteins and their annotated locations for XP_006231951.1

      UniProtKB/TrEMBL
      A0A8I6G7L9, A6I5F7
      Conserved Domains (1) summary
      pfam11802
      Location:11 → 267
      CENP-K; Centromere-associated protein K

    3. XM_039101934.1 → XP_038957862.1  centromere protein K isoform X3

      Conserved Domains (1) summary
      pfam11802
      Location:1 → 164
      CENP-K; Centromere-associated protein K

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106407.1: Suppressed sequence

      Description
      NM_001106407.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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