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    Pik3c2g phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116720, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pik3c2gprovided by RGD
    Official Full Name
    phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gammaprovided by RGD
    Primary source
    RGD:620231
    See related
    Ensembl:ENSRNOG00000034228 AllianceGenome:RGD:620231
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRG00132
    Summary
    Enables 1-phosphatidylinositol-4-phosphate 3-kinase activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase signaling; phosphatidylinositol-3-phosphate biosynthetic process; and viral RNA genome replication. Located in Golgi apparatus; nuclear envelope; and plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 93.3) and Uterus (RPKM 3.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q44
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (174215527..174583378)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (172483752..172851623)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (173732196..174102502)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547697 Neighboring gene RERG like Neighboring gene uncharacterized LOC120102423 Neighboring gene phospholipase C, zeta 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning. Carini R, et al. Gastroenterology, 2004 Sep. PMID 15362046
    2. Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Yang KY, et al. Cell Signal, 2003 Feb. PMID 12464394
    3. Inhibition of class II phosphoinositide 3-kinase gamma expression by p185(Bcr-Abl) contributes to impaired chemotaxis and aberrant homing of leukemic cells. Yu W, et al. Leuk Lymphoma, 2010 Jun. PMID 20536348, Free PMC Article
    4. Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. Daimon M, et al. Biochem Biophys Res Commun, 2008 Jan 18. PMID 17991425
    5. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. Shanley LJ, et al. J Physiol, 2002 Dec 15. PMID 12482897, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Leptin, via PI 3-kinase-driven activation of BK channels, elicits novel mechanism for controlling neuronal excitability. Novel action of leptin could provide an alternative therapeutic target in the management of epilepsy.
      Title: Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels.
    2. By regulating PKC-/delta-dependent signals, PI3K can play a key role in the development of hepatic tolerance to hypoxia/reperfusion.
      Title: Role of phosphatidylinositol 3-kinase in the development of hepatocyte preconditioning.
    3. PI3-Kgamma directly participates in multiple in vivo pathways involved in regulating neutrophil apoptosis.
      Title: Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables 1-phosphatidylinositol 4-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol 3-kinase C2 domain-containing subunit gamma
    Names
    PI3K-C2-gamma
    PI3K-C2gamma
    phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
    phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma
    phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide
    phosphoinositide 3-Kinase-C2-gamma
    phosphoinositide-3-kinase, class 2, gamma polypeptide
    ptdIns-3-kinase C2 gamma
    ptdIns-3-kinase C2 subunit gamma
    NP_446375.1
    XP_038962876.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053923.1 → NP_446375.1  phosphatidylinositol 3-kinase C2 domain-containing subunit gamma

      See identical proteins and their annotated locations for NP_446375.1

      Status: PROVISIONAL

      Source sequence(s)
      AB009636
      UniProtKB/Swiss-Prot
      O70173
      UniProtKB/TrEMBL
      A6IMM4
      Related
      ENSRNOP00000043855.4, ENSRNOT00000041499.5
      Conserved Domains (6) summary
      cd04012
      Location:535 → 697
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cl00271
      Location:712 → 879
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl02484
      Location:310 → 368
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl02563
      Location:1267 → 1367
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl14603
      Location:1389 → 1501
      C2; C2 domain
      cl21453
      Location:886 → 1238
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      174215527..174583378
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106948.2 → XP_038962876.1  phosphatidylinositol 3-kinase C2 domain-containing subunit gamma isoform X1

      UniProtKB/TrEMBL
      A6IMM4, D3ZE56
      Conserved Domains (6) summary
      cd04012
      Location:535 → 697
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cl00271
      Location:712 → 879
      PI3Ka; Phosphoinositide 3-kinase family, accessory domain (PIK domain); PIK domain is conserved in PI3 and PI4-kinases. Its role is unclear, but it has been suggested to be involved in substrate presentation. Phosphoinositide 3-kinases play an important role in ...
      cl02484
      Location:310 → 368
      PI3K_rbd; PI3-kinase family, ras-binding domain
      cl02563
      Location:1267 → 1367
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl14603
      Location:1389 → 1501
      C2; C2 domain
      cl21453
      Location:886 → 1238
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_010065609.1 RNA Sequence

    2. XR_005503143.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O70173.1 GenPept UniProtKB/Swiss-Prot:O70173

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