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    Nadk NAD kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100125370, updated on 11-Apr-2024

    Summary

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    Symbol
    Nadkprovided by RGD
    Full Name
    NAD kinaseprovided by RGD
    Primary source
    RGD:1642420
    See related
    Ensembl:ENSRNOG00000016936 AllianceGenome:RGD:1642420
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NAD+ kinase activity. Involved in NADP biosynthetic process and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Orthologous to human NADK (NAD kinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 321.0), Adrenal (RPKM 304.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q36
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (171427973..171458586)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (166145708..166176328)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (172984930..173015505)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 52 Neighboring gene G protein subunit beta 1 Neighboring gene uncharacterized LOC120103052 Neighboring gene ATP synthase peripheral stalk subunit d, pseudogene 1 Neighboring gene uncharacterized LOC134487048 Neighboring gene solute carrier family 35, member E2B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells. Gray JP, et al. Am J Physiol Endocrinol Metab, 2012 Jul 15. PMID 22550069, Free PMC Article
    2. MNADK, a Long-Awaited Human Mitochondrion-Localized NAD Kinase. Zhang R. J Cell Physiol, 2015 Aug. PMID 25641397
    3. Structural and functional characterization of human NAD kinase. Lerner F, et al. Biochem Biophys Res Commun, 2001 Oct 19. PMID 11594753
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109551

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NAD metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in NADP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NADP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD kinase
    NP_001103148.1
    XP_006239575.1
    XP_006239576.1
    XP_038965017.1
    XP_038965018.1
    XP_038965019.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109678.1 → NP_001103148.1  NAD kinase

      See identical proteins and their annotated locations for NP_001103148.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473968
      UniProtKB/TrEMBL
      A0A8I5ZN26, A6IUQ7, F7EXV6
      Related
      ENSRNOP00000022900.5, ENSRNOT00000022900.6
      Conserved Domains (1) summary
      cl01255
      Location:98 → 429
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      171427973..171458586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109091.2 → XP_038965019.1  NAD kinase isoform X5

      Conserved Domains (1) summary
      cl01255
      Location:130 → 353
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. XM_039109089.2 → XP_038965017.1  NAD kinase isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZN26
      Conserved Domains (1) summary
      cl28462
      Location:128 → 472
      pnk; bifunctional NADP phosphatase/NAD kinase

    3. XM_006239513.5 → XP_006239575.1  NAD kinase isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZN26, A0A8I6AFT7
      Related
      ENSRNOP00000093005.1
      Conserved Domains (1) summary
      cl01255
      Location:130 → 461
      DAGK_cat; Diacylglycerol kinase catalytic domain

    4. XM_039109090.2 → XP_038965018.1  NAD kinase isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZN26, Q5FVF8
      Conserved Domains (1) summary
      cl28462
      Location:96 → 440
      pnk; bifunctional NADP phosphatase/NAD kinase

    5. XM_006239514.4 → XP_006239576.1  NAD kinase isoform X4

      See identical proteins and their annotated locations for XP_006239576.1

      UniProtKB/TrEMBL
      A0A8I5ZN26, A6IUQ7, F7EXV6
      Related
      ENSRNOP00000079254.1
      Conserved Domains (1) summary
      cl01255
      Location:98 → 429
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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