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    Rspry1 ring finger and SPRY domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689249, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Rspry1provided by RGD
    Official Full Name
    ring finger and SPRY domain containing 1provided by RGD
    Primary source
    RGD:1308847
    See related
    Ensembl:ENSRNOG00000060931 AllianceGenome:RGD:1308847
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308847
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human RSPRY1 (ring finger and SPRY domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 186.1), Thymus (RPKM 115.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rspry1 in Genome Data Viewer
    Location:
    19p13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (10358423..10408988, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (10352449..10403015, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (10770572..10826895, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene plasmolipin Neighboring gene ADP-ribosylation factor like GTPase 2 binding protein Neighboring gene small nucleolar RNA SNORA5 Neighboring gene proteasome activator subunit 3 interacting protein 1 Neighboring gene uncharacterized LOC134483687 Neighboring gene copine 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156751

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING finger and SPRY domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100945.1 → NP_001094415.1  RING finger and SPRY domain-containing protein 1 precursor

      See identical proteins and their annotated locations for NP_001094415.1

      Status: PROVISIONAL

      Source sequence(s)
      BC129112
      UniProtKB/TrEMBL
      A1L1K9
      Related
      ENSRNOP00000071830.2, ENSRNOT00000090217.2
      Conserved Domains (2) summary
      pfam13920
      Location:523 → 568
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
      cd12883
      Location:359 → 479
      SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      10358423..10408988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097997.2 → XP_038953925.1  RING finger and SPRY domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K1G4, A6JY57
      Conserved Domains (2) summary
      cd12883
      Location:359 → 479
      SPRY_RING; SPRY domain at N-terminus of Really Interesting New Gene (RING) finger domain
      cd16566
      Location:525 → 565
      RING-HC_RSPRY1; RING finger, HC subclass, found in RING finger and SPRY domain-containing protein 1 (RSPRY1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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