TRIP13 thyroid hormone receptor interactor 13 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIP13provided by HGNC
Official Full Name: thyroid hormone receptor interactor 13provided by HGNC
Primary source: HGNC:HGNC:12307
See related: Ensembl:ENSG00000071539 MIM:604507; AllianceGenome:HGNC:12307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MVA3; OOMD9; 16E1BP; OZEMA9
Summary: This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
Expression: Biased expression in testis (RPKM 14.2), lymph node (RPKM 3.0) and 10 other tissues See more
Orthologs: mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5p15.33

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (892884..919348)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (798936..824664)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (892999..918235)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma.
Title: Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma.
Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma.
Title: Aberrant activation of TRIP13-EZH2 signaling axis promotes stemness and therapy resistance in multiple myeloma.
Novel mutations in TRIP13 lead to female infertility with oocyte maturation arrest.
Title: Novel mutations in TRIP13 lead to female infertility with oocyte maturation arrest.
TRIP13 overexpression promotes gefitinib resistance in nonsmall cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.
Title: TRIP13 overexpression promotes gefitinib resistance in non‑small cell lung cancer via regulating autophagy and phosphorylation of the EGFR signaling pathway.
MiR-129-5p/TRIP13 affects malignant phenotypes of colorectal cancer cells.
Title: MiR-129-5p/TRIP13 affects malignant phenotypes of colorectal cancer cells.
Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.
Title: Trip13 Depletion in Liver Cancer Induces a Lipogenic Response Contributing to Plin2-Dependent Mitotic Cell Death.
Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers.
Title: Combined TRIP13 and Aurora Kinase Inhibition Induces Apoptosis in Human Papillomavirus-Driven Cancers.
TRIP13 Induces Nedaplatin Resistance in Esophageal Squamous Cell Carcinoma by Enhancing Repair of DNA Damage and Inhibiting Apoptosis.
Title: TRIP13 Induces Nedaplatin Resistance in Esophageal Squamous Cell Carcinoma by Enhancing Repair of DNA Damage and Inhibiting Apoptosis.
Evaluation of the TRIP13 level in breast cancer and insights into potential molecular pathways.
Title: Evaluation of the TRIP13 level in breast cancer and insights into potential molecular pathways.
TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells.
Title: TRIP13 knockdown inhibits the proliferation, migration, invasion, and promotes apoptosis by suppressing PI3K/AKT signaling pathway in U2OS cells.

Submit: New GeneRIF Correction See all GeneRIFs (48)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Mosaic variegated aneuploidy syndrome 3 MedGen: C4539839 OMIM: 617598 GeneReviews: Not available	Compare labs
Oocyte maturation defect 9 MedGen: C5436599 OMIM: 619011 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein	Gene	Interaction	Pubs
Rev	rev	HIV-1 Rev interacting protein, thyroid hormone receptor interactor 13 (TRIP13), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

L18426 (e-PCR)
- UniSTS:34648

SHGC-31846 (e-PCR)
- UniSTS:15507

RH76617 (e-PCR)
- UniSTS:91347

RH12369 (e-PCR)
- UniSTS:40147

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	NAS Non-traceable Author Statement more info	PubMed
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
involved_in female meiosis I	IEA Inferred from Electronic Annotation more info
involved_in male meiosis I	IEA Inferred from Electronic Annotation more info
involved_in meiotic recombination checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte maturation	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	ISS Inferred from Sequence or Structural Similarity more info
involved_in spermatid development	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptonemal complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in male germ cell nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: pachytene checkpoint protein 2 homolog

Names: 16E1-BP; HPV16 E1 protein binding protein; SH3TC1/TRIP13 fusion; TR-interacting protein 13; TRIP-13; human papillomavirus type 16 E1 protein-binding protein; thyroid receptor-interacting protein 13

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166260.2 → NP_001159732.1 pachytene checkpoint protein 2 homolog isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC122719, AK310376

UniProtKB/TrEMBL

H0YAL2

Related

ENST00000512024.5

Conserved Domains (2) summary

COG0464
Location:136 → 289

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

pfam00004
Location:175 → 285

AAA; ATPase family associated with various cellular activities (AAA)
NM_004237.4 → NP_004228.1 pachytene checkpoint protein 2 homolog isoform 1

See identical proteins and their annotated locations for NP_004228.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC122719, BC019294, BM999741, DB443523

Consensus CDS

CCDS3858.1

UniProtKB/Swiss-Prot

C9K0T3, D3DTC0, O15324, Q15645

Related

ENSP00000166345.3, ENST00000166345.8

Conserved Domains (1) summary

COG0464
Location:136 → 360

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

892884..919348

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011514163.2 → XP_011512465.1 pachytene checkpoint protein 2 homolog isoform X1

See identical proteins and their annotated locations for XP_011512465.1

UniProtKB/Swiss-Prot

C9K0T3, D3DTC0, O15324, Q15645

Conserved Domains (1) summary

COG0464
Location:136 → 360

SpoVK; AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms]
XM_047417879.1 → XP_047273835.1 pachytene checkpoint protein 2 homolog isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

798936..824664

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054353801.1 → XP_054209776.1 pachytene checkpoint protein 2 homolog isoform X1

UniProtKB/Swiss-Prot

C9K0T3, D3DTC0, O15324, Q15645
XM_054353802.1 → XP_054209777.1 pachytene checkpoint protein 2 homolog isoform X2