LMAN2 lectin, mannose binding 2 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: LMAN2provided by VGNC
Official Full Name: lectin, mannose binding 2provided by VGNC
Primary source: VGNC:VGNC:42708
See related: Ensembl:ENSCAFG00845010502
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: VIP36
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	4	NC_051808.1 (36369371..36390131)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	4	NC_006586.4 (35970558..35991241)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	4	NC_049225.1 (36890050..36910748)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	4	NC_049264.1 (36194590..36215063)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	4	NC_049745.1 (36380795..36401235)

Chromosome 4 - NC_051808.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP facilitates the entry and LMAN2 impedes the exit of the flux, respectively.
Title: Adaptor Protein CD2AP and L-type Lectin LMAN2 Regulate Exosome Cargo Protein Trafficking through the Golgi Complex.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables mannose binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endoplasmic reticulum organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	IEA Inferred from Electronic Annotation more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in endoplasmic reticulum-Golgi intermediate compartment	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: vesicular integral-membrane protein VIP36

Names: vesicular integral-membrane protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003258.2 → NP_001003258.1 vesicular integral-membrane protein VIP36 precursor

See identical proteins and their annotated locations for NP_001003258.1

Status: PROVISIONAL

Source sequence(s)

X76392

UniProtKB/Swiss-Prot

P49256

UniProtKB/TrEMBL

A0A8C0KD70, A0A8C0KGI3

Related

ENSCAFP00845014570.1, ENSCAFT00845018663.1

Conserved Domains (1) summary

cd06901
Location:53 → 301

lectin_VIP36_VIPL; VIP36 and VIPL type 1 transmembrane proteins, lectin domain