RAB11A RAB11A, member RAS oncogene family [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB11Aprovided by HGNC
Official Full Name: RAB11A, member RAS oncogene familyprovided by HGNC
Primary source: HGNC:HGNC:9760
See related: Ensembl:ENSG00000103769 MIM:605570; AllianceGenome:HGNC:9760
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: YL8
Summary: The protein encoded by this gene belongs to the Rab family of the small GTPase superfamily. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Expression: Ubiquitous expression in esophagus (RPKM 50.5), adrenal (RPKM 37.5) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q22.31

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (65869491..65891989)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (63678915..63701413)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (66161829..66184327)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion.
Title: Rab11 suppresses head and neck carcinoma by regulating EGFR and EpCAM exosome secretion.
Rab11 and Its Role in Neurodegenerative Diseases.
Title: Rab11 and Its Role in Neurodegenerative Diseases.
SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma.
Title: SREBP2/Rab11s/GLUT1/6 network regulates proliferation and migration of glioblastoma.
Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy.
Title: Rab11a promotes the malignant progression of ovarian cancer by inducing autophagy.
RAB11A Expression Is Associated With Cancer Aggressiveness Through Regulation of FGFR-Signaling in Lung Squamous Cell Carcinoma.
Title: RAB11A Expression Is Associated With Cancer Aggressiveness Through Regulation of FGFR-Signaling in Lung Squamous Cell Carcinoma.
RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-kappaB and PI3K/AKT pathways.
Title: RAB11A aggravates PDGF-BB-stimulated proliferation, migration, and inflammation of airway smooth muscle cells via affecting the NF-κB and PI3K/AKT pathways.
TBC1 domain family member 23 interacts with Ras-related protein Rab-11A to promote poor prognosis of non-small-cell lung cancer via beta1-integrin.
Title: TBC1 domain family member 23 interacts with Ras-related protein Rab-11A to promote poor prognosis of non-small-cell lung cancer via β1-integrin.
Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation.
Title: Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation.
Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
Title: Tankyrase regulates epithelial lumen formation via suppression of Rab11 GEFs.
RAB11A-mediated YAP localization to adherens and tight junctions is essential for colonic epithelial integrity.
Title: RAB11A-mediated YAP localization to adherens and tight junctions is essential for colonic epithelial integrity.

Submit: New GeneRIF Correction See all GeneRIFs (101)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of RAB11A, member RAS oncogene family (RAB11A) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed
Knockdown of RAB11A, member RAS oncogene family (RAB11A) by siRNA inhibits HIV-1 replication in CD4+/CCR5+/CXCR4+ TZM-bl HeLa cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 interacts with RAB11A; predicted interaction to be relevant to vesicular transport/membrane trafficking	PubMed
Nef	nef	HIV-1 Nef co-localization with Rab11A GTPase is revealed by staining in the peripheral and perinuclear compartments	PubMed
	nef	RAB11(Q67L) mutant induces significant reversal of HLA-I A2 downregulation by HIV-1 Nef through redistributing HLA-I A2 from the perinuclear vesicles to the peripheral punctate vesicles at the plasma membrane	PubMed
Pr55(Gag)	gag	Rab11a modulates intracellular Gag expression in human cells	PubMed
	gag	HIV-1 Gag and viral RNA preferentially co-localize with multivesicular bodies and Rab11a endosomes	PubMed
capsid	gag	Overexpression of a dominant negative Rab-11 GTPase mutant reduces the release of HIV-1 by CA levels and increases the intracellular CA accumulation	PubMed
reverse transcriptase	gag-pol	The highest RT activity is found in Rab11a compartments and Rab7a compartments in nontreated cells after 7 and 14 days of HIV-1 challenge, respectively, suggesting that the virus is mainly located in these endosomal compartments	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-82517 (e-PCR)
- UniSTS:104463

WI-15108 (e-PCR)
- UniSTS:83480

D8S2279 (e-PCR)
- UniSTS:473907

D15S728E (e-PCR)
- UniSTS:151622

STS-N21208 (e-PCR)
- UniSTS:22088

1982 (e-PCR)
- UniSTS:17748

RAB11A_474 (e-PCR)
- UniSTS:277632

A008D11 (e-PCR)
- UniSTS:63361

D15S913 (e-PCR)
- UniSTS:53930

D15S857 (e-PCR)
- UniSTS:153537

RH80236 (e-PCR)
- UniSTS:83908

D15S710E (e-PCR)
- UniSTS:21195

WI-17132 (e-PCR)
- UniSTS:10960

RAB11A (e-PCR)
- UniSTS:264165

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IC Inferred by Curator more info	PubMed
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables dynein light intermediate chain binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin V binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables syntaxin binding	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane protein transport	IC Inferred by Curator more info	PubMed
involved_in amyloid-beta clearance by transcytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in astral microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in early endosome to recycling endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of vesicle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in exosomal secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in melanosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in melanosome transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multivesicular body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane to endosome transport	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cytokinetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cilium	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of cilium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of early endosome to recycling endosome transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of endocytic recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of multivesicular body size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to centrosome	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	HDA more info	PubMed
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in centriolar satellite	IDA Inferred from Direct Assay more info
located_in centriole	IEA Inferred from Electronic Annotation more info
colocalizes_with centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle membrane	TAS Traceable Author Statement more info
located_in cytosol	TAS Traceable Author Statement more info
located_in endocytic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
colocalizes_with kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic recycling endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic recycling endosome	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	TAS Traceable Author Statement more info
located_in spindle pole	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
is_active_in trans-Golgi network membrane	IC Inferred by Curator more info	PubMed
located_in trans-Golgi network membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in transport vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ras-related protein Rab-11A

Names: RAB 11A, member oncogene family; rab-11

NP_001193765.1

EC 3.6.5.2

NP_004654.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001206836.2 → NP_001193765.1 ras-related protein Rab-11A isoform 2

See identical proteins and their annotated locations for NP_001193765.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform a.

Source sequence(s)

AC084854, AK300008, BC013348, BC047114, DC300743

Consensus CDS

CCDS58373.1

UniProtKB/TrEMBL

H3BMH2

Related

ENSP00000456420.1, ENST00000569896.1

Conserved Domains (1) summary

cd01868
Location:9 → 146

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25
NM_004663.5 → NP_004654.1 ras-related protein Rab-11A isoform 1

See identical proteins and their annotated locations for NP_004654.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC084854, BC013348, BC047114, DC300743

Consensus CDS

CCDS10212.1

UniProtKB/Swiss-Prot

B2R4B6, B4DT13, P24410, P62491, Q5TZN9, Q9JLX1

UniProtKB/TrEMBL

B4DMN1

Related

ENSP00000261890.2, ENST00000261890.7

Conserved Domains (1) summary

cd01868
Location:9 → 173

Rab11_like; Rab GTPase family 11 (Rab11)-like includes Rab11a, Rab11b, and Rab25