ACP3 acid phosphatase 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ACP3provided by HGNC
Official Full Name: acid phosphatase 3provided by HGNC
Primary source: HGNC:HGNC:125
See related: Ensembl:ENSG00000014257 MIM:171790; AllianceGenome:HGNC:125
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ACPP; 5'-NT; ACP-3; TM-PAP
Summary: This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
Expression: Restricted expression toward prostate (RPKM 1149.8) See more
Orthologs: mouse all
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Genomic context

Location:: 3q22.1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (132317407..132368302)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (135061847..135112776)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (132036251..132087146)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Purification, identification and Cryo-EM structure of prostatic acid phosphatase in human semen.
Title: Purification, identification and Cryo-EM structure of prostatic acid phosphatase in human semen.
Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis.
Title: Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis.
Enhanced TDPase and TMPase activities may contribute to the reduction of TDP level in AD patients. The results imply that an imbalance of phosphorylation-dephosphorylation related to thiamine and glucose metabolism may be a potential target for AD prevention and therapy.
Title: Enhanced Activities of Blood Thiamine Diphosphatase and Monophosphatase in Alzheimer's Disease.
Thirteen single nucleotide polymorphism (SNPs) in acid phosphatase prostate (ACPP) were suggested as candidate causal alleles that underlie ACPP regulation and expression.
Title: Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels.
we have measured the intramolecular diffusion of the full length and 8-residue deletion peptides at two different pHs and found a correlation with fibrillization lag time. These results can be explained by a simple kinetic model of the early stages of aggregation in which oligomerization is controlled by the rate of peptide reconfiguration.
Title: Intramolecular diffusion controls aggregation of the PAPf39 peptide.
Prostatic acid phosphatase delays prostate cancer cell growth in G1 phase of the cell cycle.
Title: Transmembrane prostatic acid phosphatase (TMPAP) delays cells in G1 phase of the cell cycle.
Studies suggest that understanding of prostatic acid phosphatase function and regulation of expression will have a significant impact on understanding prostate cancer (PCa) progression and therapy.
Title: Human prostatic acid phosphatase: structure, function and regulation.
Certain factors identified within semen, termed semen-derived enhancers of virus infection (SEVI), fragments of prostatic acid phosphatase, have been shown to significantly enhance HIV-1 infectivity.
Title: Characterization of the Influence of Semen-Derived Enhancer of Virus Infection on the Interaction of HIV-1 with Female Reproductive Tract Tissues.
ACPP increases significantly in epithelial cells of ovarian carcinoma, which indicates that it may be a candidate biomarker for diagnosis of epithelia-derived ovarian cancer in women.
Title: Avian prostatic acid phosphatase: estrogen regulation in the oviduct and epithelial cell-derived ovarian carcinomas.
Data indicate that hypoxia regulates prostatic acid phosphatase (PAP) through hypoxia-inducible factor 2 alpha (HIF2alpha) and from stimulated A2B adenosine receptors.
Title: The HIF-2alpha dependent induction of PAP and adenosine synthesis regulates glioblastoma stem cell function through the A2B adenosine receptor.

Submit: New GeneRIF Correction See all GeneRIFs (44)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:455656 (e-PCR)
- UniSTS:157467

STS-M24902 (e-PCR)
- UniSTS:47449

GDB:181274 (e-PCR)
- UniSTS:155234

SHGC-62995 (e-PCR)
- UniSTS:95380

G10726 (e-PCR)
- UniSTS:61382

D3S1596 (e-PCR)
- UniSTS:18137

GDB:180742 (e-PCR)
- UniSTS:155117

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables 5'-nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables XMP 5'-nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables acid phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables acid phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables choline binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lysophosphatidic acid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables thiamine phosphate phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adenosine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lysosome organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of adenosine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of sensory perception of pain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thiamine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi cisterna	IEA Inferred from Electronic Annotation more info
located_in apical part of cell	IEA Inferred from Electronic Annotation more info
located_in azurophil granule membrane	TAS Traceable Author Statement more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IMP Inferred from Mutant Phenotype more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	HDA more info	PubMed
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in multivesicular body	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prostatic acid phosphatase

Names: TMPase; acid phosphatase, prostate; ecto-5'-nucleotidase; prostatic acid phosphotase; protein tyrosine phosphatase ACP3; thiamine monophosphatase

NP_001090.2

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

NP_001127666.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

NP_001278966.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

XP_011511248.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

XP_011511249.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

XP_054203008.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

XP_054203009.1

EC 3.1.3.2

EC 3.1.3.48

EC 3.1.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_047032.1 RefSeqGene

Range

5041..46475

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001099.5 → NP_001090.2 prostatic acid phosphatase isoform PAP precursor

See identical proteins and their annotated locations for NP_001090.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the shorter, secreted isoform (PAP).

Source sequence(s)

AA578274, AC020633, BC008493, BC016344

Consensus CDS

CCDS3073.1

UniProtKB/Swiss-Prot

D3DNC6, P15309, Q5FBY0, Q96KY0, Q96QK9, Q96QM0

Related

ENSP00000337471.5, ENST00000336375.10

Conserved Domains (1) summary

cd07061
Location:34 → 332

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
NM_001134194.2 → NP_001127666.1 prostatic acid phosphatase isoform TM-PAP precursor

See identical proteins and their annotated locations for NP_001127666.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs at the 3' end compared to variant 1 and encodes a longer isoform (TM-PAP) with a distinct C-terminus compared to isoform PAP. TM-PAP is a type 1 transmembrane protein.

Source sequence(s)

AW136372, BC007460, BC008493, BQ100881, DC383453

Consensus CDS

CCDS46916.1

UniProtKB/Swiss-Prot

P15309

Related

ENSP00000323036.8, ENST00000351273.12

Conserved Domains (1) summary

cd07061
Location:34 → 332

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
NM_001292037.2 → NP_001278966.1 prostatic acid phosphatase isoform 3 precursor

See identical proteins and their annotated locations for NP_001278966.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform PAP.

Source sequence(s)

AC020633, AK300540, DC383453

Consensus CDS

CCDS77818.1

UniProtKB/Swiss-Prot

P15309

Related

ENSP00000417744.1, ENST00000475741.5

Conserved Domains (1) summary

cd07061
Location:34 → 299

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

132317407..132368302

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011512947.3 → XP_011511249.1 prostatic acid phosphatase isoform X2

Conserved Domains (1) summary

cd07061
Location:34 → 299

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
XM_011512946.2 → XP_011511248.1 prostatic acid phosphatase isoform X1

Conserved Domains (1) summary

cd07061
Location:34 → 332

HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction