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    Plek pleckstrin [ Mus musculus (house mouse) ]

    Gene ID: 56193, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Plekprovided by MGI
    Official Full Name
    pleckstrinprovided by MGI
    Primary source
    MGI:MGI:1860485
    See related
    Ensembl:ENSMUSG00000020120 AllianceGenome:MGI:1860485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2010300B13Rik
    Summary
    Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity; protein homodimerization activity; and protein kinase C binding activity. Involved in several processes, including exocytosis; platelet aggregation; and positive regulation of cellular component organization. Predicted to be located in cytoplasm and ruffle membrane. Predicted to be active in plasma membrane. Orthologous to human PLEK (pleckstrin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in liver E14 (RPKM 8.7), liver E14.5 (RPKM 6.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Plek in Genome Data Viewer
    Location:
    11 A2; 11 9.41 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (16921206..16958718, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (16971206..17008718, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene epidermal growth factor receptor Neighboring gene epidermal growth factor receptor, opposite strand Neighboring gene STARR-seq mESC enhancer starr_28697 Neighboring gene STARR-seq mESC enhancer starr_28698 Neighboring gene STARR-seq mESC enhancer starr_28699 Neighboring gene STARR-seq mESC enhancer starr_28700 Neighboring gene Egfr long non-coding downstream RNA Neighboring gene F-box protein 48 Neighboring gene STARR-positive B cell enhancer ABC_E8386 Neighboring gene STARR-positive B cell enhancer ABC_E1819 Neighboring gene signal peptide, CUB domain, EGF-like 3 pseudogene Neighboring gene predicted gene, 53668

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain. Meuillet EJ. Curr Med Chem, 2011. PMID 21649580, Free PMC Article
    2. Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis. Lian L, et al. Blood, 2009 Apr 9. PMID 19190246, Free PMC Article
    3. cDNA cloning and mapping of mouse pleckstrin (Plek), a gene upregulated in transformation-resistant cells. Cmarik JL, et al. Genomics, 2000 Jun 1. PMID 10860665
    4. DLK1 is a novel regulator of bone mass that mediates estrogen deficiency-induced bone loss in mice. Abdallah BM, et al. J Bone Miner Res, 2011 Jul. PMID 21308776
    5. The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells. Ray JP, et al. Immunity, 2015 Oct 20. PMID 26410627, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting of the pleckstrin homology domain of AKT was studied in cancer treatment in mouse models.
      Title: Novel inhibitors of AKT: assessment of a different approach targeting the pleckstrin homology domain.
    2. pleckstrin regulates the fusion of granules to the cell membrane and is an essential component of PKC-mediated exocytosis in platelets
      Title: Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-3,4-bisphosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell projection organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cortical actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inositol phosphate biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phospholipase C-inhibiting G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of actin filament depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inositol-polyphosphate 5-phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of integrin activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of platelet activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein kinase C signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion by platelet IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell diameter ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ruffle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thrombin-activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thrombin-activated receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vesicle docking involved in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019549.2 → NP_062422.1  pleckstrin

      See identical proteins and their annotated locations for NP_062422.1

      Status: VALIDATED

      Source sequence(s)
      AK151460, BY149522, CJ198197
      Consensus CDS
      CCDS24446.1
      UniProtKB/Swiss-Prot
      Q9ERI9, Q9JHK5
      UniProtKB/TrEMBL
      Q5F271, Q8C6F4
      Related
      ENSMUSP00000099945.4, ENSMUST00000102881.10
      Conserved Domains (4) summary
      cd04445
      Location:125 → 223
      DEP_PLEK1; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in pleckstrin 1-like proteins. Pleckstrin 1 plays a role in cell spreading and reorganization of actin cytoskeleton in platelets and leukocytes. Its activity is highly regulated by phosphorylation, ...
      cd13301
      Location:3 → 110
      PH1_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 1
      cd13302
      Location:239 → 346
      PH2_Pleckstrin_2; Pleckstrin 2 Pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:6 → 101
      PH; PH domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      16921206..16958718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JHK5.1 GenPept UniProtKB/Swiss-Prot:Q9JHK5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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