Ptgdr2 prostaglandin D2 receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgdr2provided by MGI
Official Full Name: prostaglandin D2 receptor 2provided by MGI
Primary source: MGI:MGI:1330275
See related: Ensembl:ENSMUSG00000034117 AllianceGenome:MGI:1330275
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crth2; Gpr44; Grp45
Summary: Enables prostaglandin D receptor activity; prostaglandin F receptor activity; and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of male germ cell proliferation; and positive regulation of G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR2 (prostaglandin D2 receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 2.6), subcutaneous fat pad adult (RPKM 1.9) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 7.4 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (10901883..10919875)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (10924519..10942511)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DP1 (Prostaglandin D2 Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice.
Title: DP1 (Prostaglandin D(2) Receptor 1) Activation Protects Against Vascular Remodeling and Vascular Smooth Muscle Cell Transition to Myofibroblasts in Angiotensin II-Induced Hypertension in Mice.
Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation.
Title: Role of prostaglandin D2 receptors in the pathogenesis of abdominal aortic aneurysm formation.
PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection.
Title: PGD2 and CRTH2 counteract Type 2 cytokine-elicited intestinal epithelial responses during helminth infection.
ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6.
Title: ER-anchored CRTH2 antagonizes collagen biosynthesis and organ fibrosis via binding LARP6.
The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung.
Title: The Prostaglandin D(2) Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung.
tudies present a novel regulatory role for Crth2 during inflammatory response in macrophages
Title: Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium.
Prostaglandin D2 (DP2) receptor expression is highest when the hair follicle begins regressing in hair growth cycles in mice strongly suggesting that the PGD2-DP2 receptor pathway plays a key role in the inhibition of hair growth.
Title: Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression.
The disease model is driven by gammadeltaT cells that express CRTH2.
Title: Deficiency of CRTH2, a Prostaglandin D(2) Receptor, Aggravates Bleomycin-induced Pulmonary Inflammation and Fibrosis.
Our study revealed that rising temperature of POA alters the activity of Ptgds-expressing neurons so as to increase PGD2 production.
Title: Thermoregulation via Temperature-Dependent PGD(2) Production in Mouse Preoptic Area.
the beneficial effects of DP2 blockade or DP1 agonism were associated with increased interferon-lambda (IFN-lambda) [interleukin-28A/B (IL-28A/B)] expression and were lost upon IL-28A neutralization.
Title: PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables G protein-coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin D receptor activity	ISO Inferred from Sequence Orthology more info
enables prostaglandin F receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin J receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemotaxis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within negative regulation of male germ cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: prostaglandin D2 receptor 2

Names: G-protein coupled receptor 44; PGD2 receptor; chemoattractant receptor-homologous molecule expressed on TH2 cells; prostaglandin D2 receptor CRTH2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009962.3 → NP_034092.1 prostaglandin D2 receptor 2

See identical proteins and their annotated locations for NP_034092.1

Status: VALIDATED

Source sequence(s)

AC132402, AC148991, AK041947

Consensus CDS

CCDS29592.1

UniProtKB/Swiss-Prot

Q54A00, Q9Z2J6

Related

ENSMUSP00000036159.4, ENSMUST00000037261.4

Conserved Domains (2) summary

cd14964
Location:34 → 58

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 314

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

10901883..10919875

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011247148.4 → XP_011245450.1 prostaglandin D2 receptor 2 isoform X1

See identical proteins and their annotated locations for XP_011245450.1

UniProtKB/Swiss-Prot

Q54A00, Q9Z2J6

Conserved Domains (2) summary

cd14964
Location:34 → 58

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 314

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006526695.5 → XP_006526758.1 prostaglandin D2 receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006526758.1

UniProtKB/Swiss-Prot

Q54A00, Q9Z2J6

Conserved Domains (2) summary

cd14964
Location:34 → 58

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 314

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_006526696.5 → XP_006526759.1 prostaglandin D2 receptor 2 isoform X1

See identical proteins and their annotated locations for XP_006526759.1

UniProtKB/Swiss-Prot

Q54A00, Q9Z2J6

Conserved Domains (2) summary

cd14964
Location:34 → 58

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:32 → 314

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily