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    Pds5b PDS5 cohesin associated factor B [ Mus musculus (house mouse) ]

    Gene ID: 100710, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pds5bprovided by MGI
    Official Full Name
    PDS5 cohesin associated factor Bprovided by MGI
    Primary source
    MGI:MGI:2140945
    See related
    Ensembl:ENSMUSG00000034021 AllianceGenome:MGI:2140945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AS3; Aprin; WAP-Her-2; mKIAA0979; Tg(Wap-ERBB2)229Wzw
    Summary
    Predicted to enable DNA binding activity. Acts upstream of or within lens development in camera-type eye and neuroblast migration. Predicted to be located in nucleoplasm. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PDS5B (PDS5 cohesin associated factor B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 11.8), limb E14.5 (RPKM 9.2) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 G3; 5 89.61 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (150597178..150734174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (150673713..150810669)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene breast cancer 2, early onset Neighboring gene predicted gene 42529 Neighboring gene STARR-positive B cell enhancer ABC_E3639 Neighboring gene STARR-positive B cell enhancer mm9_chr5:151397981-151398282 Neighboring gene STARR-seq mESC enhancer starr_14956 Neighboring gene NEDD4 binding protein 2-like 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:151414417-151414570 Neighboring gene STARR-positive B cell enhancer ABC_E10368 Neighboring gene STARR-positive B cell enhancer ABC_E2774 Neighboring gene NEDD4 binding protein 2-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E6410 Neighboring gene STARR-positive B cell enhancer ABC_E6411 Neighboring gene STARR-positive B cell enhancer ABC_E3640 Neighboring gene STARR-seq mESC enhancer starr_14958 Neighboring gene STARR-positive B cell enhancer ABC_E4810 Neighboring gene predicted gene, 40353 Neighboring gene predicted gene, 24630 Neighboring gene predicted gene, 26013 Neighboring gene STARR-seq mESC enhancer starr_14960 Neighboring gene predicted gene, 36447 Neighboring gene STARR-seq mESC enhancer starr_14962 Neighboring gene STARR-seq mESC enhancer starr_14963 Neighboring gene klotho

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity. Lai J, et al. Nat Immunol, 2020 Aug. PMID 32424363
    2. Overexpression of APRIN inhibits differentiation and proliferation and promotes apoptosis in P19 embryonal carcinoma cells. Zhou X, et al. Mol Biol Rep, 2013 Jan. PMID 23054015
    3. A better immune reaction to Erbb-2 tumors is elicited in mice by DNA vaccines encoding rat/human chimeric proteins. Quaglino E, et al. Cancer Res, 2010 Apr 1. PMID 20332241
    4. Dendritic cells pulsed with an anti-idiotype antibody mimicking Her-2/neu induced protective antitumor immunity in two lines of Her-2/neu transgenic mice. Saha A, et al. Cell Immunol, 2010. PMID 20236626
    5. Combining human and rat sequences in her-2 DNA vaccines blunts immune tolerance and drives antitumor immunity. Jacob JB, et al. Cancer Res, 2010 Jan 1. PMID 20048073, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A.
      Title: Circular RNA CircPDS5B impairs angiogenesis following ischemic stroke through its interaction with hnRNPL to inactivate VEGF-A.
    2. PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.
      Title: PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.
    3. PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.
      Title: PDS5 proteins regulate the length of axial elements and telomere integrity during male mouse meiosis.
    4. findings demonstrate that Her2+/+ mice, similar to Pds5b-/- mice, are embryonic lethal and confirm the necessity for Pds5b in embryonic development
      Title: Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene.
    5. reduced accumulation of Aurora B at the inner centromere region in cells lacking Pds5B impairs its error correction function, promoting chromosome mis-segregation and aneuploidy
      Title: Pds5B is required for cohesion establishment and Aurora B accumulation at centromeres.
    6. demonstrates that overexpression of APRIN inhibits differentiation and proliferation and promotes apoptosis in P19 embryonal carcinoma cells.
      Title: Overexpression of APRIN inhibits differentiation and proliferation and promotes apoptosis in P19 embryonal carcinoma cells.
    7. While Pds5A(-/-) and Pds5B(-/-) mice die at birth, embryos harboring 3 mutant Pds5 alleles die between E11.5 and E12.5 most likely of heart failure, indicating that total Pds5 gene dosage is critical for normal development.
      Title: Dosage effects of cohesin regulatory factor PDS5 on mammalian development: implications for cohesinopathies.
    8. APRIN, in addition to its Pds5 similarity, has the features and localization of a hormone-induced chromatin regulator.
      Title: APRIN is a unique Pds5 paralog with features of a chromatin regulator in hormonal differentiation.
    9. Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
      Title: Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
    10. A paper used gene targeting in mice to demonstrate the function of PDS5B in embryonic development.
      Title: Mice lacking sister chromatid cohesion protein PDS5B exhibit developmental abnormalities reminiscent of Cornelia de Lange syndrome.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sister chromatid cohesion protein PDS5 homolog B
    Names
    Her-2 Tg
    PDS5, regulator of cohesion maintenance, homolog B
    androgen-induced proliferation inhibitor
    androgen-induced prostate proliferative shutoff associated protein AS3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001346503.2 → NP_001333432.1  sister chromatid cohesion protein PDS5 homolog B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC111126, AC158558
      Consensus CDS
      CCDS85012.1
      UniProtKB/Swiss-Prot
      Q4VA53
      Related
      ENSMUSP00000144572.2, ENSMUST00000202170.4

    2. NM_001421228.1 → NP_001408157.1  sister chromatid cohesion protein PDS5 homolog B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC111126, AC158558

    3. NM_175310.7 → NP_780519.3  sister chromatid cohesion protein PDS5 homolog B isoform 1

      See identical proteins and their annotated locations for NP_780519.3

      Status: VALIDATED

      Source sequence(s)
      AC111126, AC158558
      Consensus CDS
      CCDS39412.1
      UniProtKB/Swiss-Prot
      Q3TNZ4, Q4VA53, Q7TSS4, Q80TM8, Q8BJ18, Q8BLH6, Q8BX77
      Related
      ENSMUSP00000016569.5, ENSMUST00000016569.11
      Conserved Domains (2) summary
      sd00044
      Location:240 → 261
      HEAT; HEAT repeat [structural motif]
      cl04813
      Location:1172 → 1275
      EIN3; Ethylene insensitive 3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      150597178..150734174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504901.2 → XP_006504964.1  sister chromatid cohesion protein PDS5 homolog B isoform X1

      UniProtKB/TrEMBL
      F8WHU5
      Related
      ENSMUSP00000038421.9, ENSMUST00000038900.15
      Conserved Domains (2) summary
      sd00044
      Location:240 → 261
      HEAT; HEAT repeat [structural motif]
      pfam07263
      Location:1175 → 1433
      DMP1; Dentin matrix protein 1 (DMP1)

    2. XM_006504904.2 → XP_006504967.1  sister chromatid cohesion protein PDS5 homolog B isoform X3

      Conserved Domains (2) summary
      sd00044
      Location:240 → 261
      HEAT; HEAT repeat [structural motif]
      pfam07263
      Location:1154 → 1412
      DMP1; Dentin matrix protein 1 (DMP1)

    3. XM_036164692.1 → XP_036020585.1  sister chromatid cohesion protein PDS5 homolog B isoform X4

      Conserved Domains (3) summary
      sd00044
      Location:240 → 261
      HEAT; HEAT repeat [structural motif]
      pfam05793
      Location:1154 → 1397
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)
      cd19953
      Location:31 → 661
      PDS5; Sister chromatid cohesion protein PDS5

    4. XM_030254020.1 → XP_030109880.1  sister chromatid cohesion protein PDS5 homolog B isoform X5

      Conserved Domains (2) summary
      sd00044
      Location:240 → 261
      HEAT; HEAT repeat [structural motif]
      pfam05793
      Location:1154 → 1396
      TFIIF_alpha; Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)

    5. XM_006504905.4 → XP_006504968.1  sister chromatid cohesion protein PDS5 homolog B isoform X6

      Conserved Domains (3) summary
      PTZ00449
      Location:801 → 1055
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      sd00044
      Location:32 → 62
      HEAT; HEAT repeat [structural motif]
      pfam07263
      Location:934 → 1192
      DMP1; Dentin matrix protein 1 (DMP1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4VA53.1 GenPept UniProtKB/Swiss-Prot:Q4VA53

    Gene LinkOut

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