Chst2 carbohydrate sulfotransferase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Chst2provided by MGI
Official Full Name: carbohydrate sulfotransferase 2provided by MGI
Primary source: MGI:MGI:1891160
See related: Ensembl:ENSMUSG00000033350 AllianceGenome:MGI:1891160
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Chts2; GST-2; Gn6st; GlcNAc6ST; C130041E03Rik
Summary: Enables sulfotransferase activity. Involved in positive regulation of leukocyte tethering or rolling. Predicted to be located in Golgi apparatus; cytosol; and nucleoplasm. Predicted to be active in trans-Golgi network. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human CHST2 (carbohydrate sulfotransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 14.1), frontal lobe adult (RPKM 12.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 50.11 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (95282979..95289323, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (95400926..95407270, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis.
Title: CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis.
These findings suggest that interactions between MAdCAM-1 and alpha4beta7 integrin and/or unsulfated sLeX and L-selectin may become a dominant mechanism for inflammatory cell recruitment in the absence of 6-sulfo sLeX and contribute to more severe colitis phenotypes seen in mice deficient in both GlcNAc6ST-1 and GlcNAc6ST-2.
Title: Role of MAdCAM-1-Expressing High Endothelial Venule-Like Vessels in Colitis Induced in Mice Lacking Sulfotransferases Catalyzing L-Selectin Ligand Biosynthesis.
GlcNAc6ST role in Alzheimer's disease pathology in microglia.
Title: Deficiency of a sulfotransferase for sialic acid-modified glycans mitigates Alzheimer's pathology.
data indicate that keratan sulfate expression is closely associated with functional disturbance after spinal cord injury; N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice are a good model to investigate the roles of keratan sulfate in the CNS
Title: N-acetylglucosamine 6-O-sulfotransferase-1-deficient mice show better functional recovery after spinal cord injury.
Essential function of N-acetylglucosamine-6-O-sulfotransferases 1 (GlcNAc6ST-1) in L-selectin ligand biosynthesis in high endothelial venules and its importance in immune surveillance was shown.(GlcNAc6ST-1)
Title: N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.
N-acetylglucosamine-6-O-sulfotransferases (GlcNAc6ST-1 and GlcNAc6ST-2) deficiency results in elimination of both peripheral node addressin and sialyl 6-sulfo Lewis X in high endothelial venules.
Title: A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules.
the sulfotransferase GlcNAc6ST-2 is induced in mouse collagen-induced arthritis.
Title: Induction of PNAd and N-acetylglucosamine 6-O-sulfotransferases 1 and 2 in mouse collagen-induced arthritis.
GlcNAc6ST-1 has a role in lymphocyte homing to Peyer's patches
Title: N-acetylglucosamine 6-O-sulfotransferase-1 regulates expression of L-selectin ligands and lymphocyte homing.
Essential function of N-acetylglucosamine-6-O-sulfotransferases 2 (GlcNAc6ST-2) in L-selectin ligand biosynthesis in high endothelial venules and its importance in immune surveillance was shown.
Title: N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

General gene information

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Markers

Chst2 (e-PCR), detects polymorphism
- UniSTS:545915

Chst2 (e-PCR), detects polymorphism
- UniSTS:527288

AW121776 (e-PCR)
- UniSTS:185802

AI428561 (e-PCR)
- UniSTS:179953

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acetylglucosamine 6-O-sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosamine 6-O-sulfotransferase activity	ISO Inferred from Sequence Orthology more info
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acetylglucosamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acetylglucosamine metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within N-acetylglucosamine metabolic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sulfur compound metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfur compound metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: carbohydrate sulfotransferase 2

Names: N-acetylglucosamine 6-O-sulfotransferase 1; N-acetylglucosamine-6-O-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 2; glcNAc6ST-1; gn6st-1

NP_061233.2

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.