U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Atp6v0d2 ATPase, H+ transporting, lysosomal V0 subunit D2 [ Mus musculus (house mouse) ]

    Gene ID: 242341, updated on 9-May-2024

    Summary

    Official Symbol
    Atp6v0d2provided by MGI
    Official Full Name
    ATPase, H+ transporting, lysosomal V0 subunit D2provided by MGI
    Primary source
    MGI:MGI:1924415
    See related
    Ensembl:ENSMUSG00000028238 AllianceGenome:MGI:1924415
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    V-ATPase; 1620401A02Rik
    Summary
    Predicted to enable proton transmembrane transporter activity. Predicted to be involved in vacuolar acidification and vacuolar transport. Predicted to act upstream of or within ion transport. Located in early endosome. Is expressed in several structures, including alimentary system; limb; metanephros; respiratory system; and skeleton. Orthologous to human ATP6V0D2 (ATPase H+ transporting V0 subunit d2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 4.2), genital fat pad adult (RPKM 2.8) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Atp6v0d2 in Genome Data Viewer
    Location:
    4 A3; 4 7.67 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (19876838..19922566, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (19876838..19922566, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12354 Neighboring gene STARR-seq mESC enhancer starr_09699 Neighboring gene STARR-seq mESC enhancer starr_09700 Neighboring gene STARR-seq mESC enhancer starr_09702 Neighboring gene solute carrier family 7, (cationic amino acid transporter, y+ system) member 13 Neighboring gene STARR-seq mESC enhancer starr_09703 Neighboring gene RIKEN cDNA 4930480G23 gene Neighboring gene STARR-seq mESC enhancer starr_09704 Neighboring gene STARR-seq mESC enhancer starr_09707 Neighboring gene tocopherol (alpha) transfer protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables proton-transporting ATPase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vacuolar acidification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in vacuolar transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in early endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of plasma membrane proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proton-transporting V-type ATPase, V0 domain IEA
    Inferred from Electronic Annotation
    more info
     
    part_of vacuolar proton-transporting V-type ATPase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of vacuolar proton-transporting V-type ATPase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    V-type proton ATPase subunit d 2
    Names
    V-ATPase subunit d 2
    osteoclast-specific vacuolar ATP synthase
    vacuolar proton pump subunit d 2
    vacuolar proton-translocating ATPase d subunit d2
    NP_780615.2
    XP_017175683.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175406.3NP_780615.2  V-type proton ATPase subunit d 2

      See identical proteins and their annotated locations for NP_780615.2

      Status: VALIDATED

      Source sequence(s)
      AK075745, AK137586, AY517482
      Consensus CDS
      CCDS17994.1
      UniProtKB/Swiss-Prot
      Q3TDQ6, Q5I0V5, Q80SY3, Q8BTL3, Q8BW16
      Related
      ENSMUSP00000029900.6, ENSMUST00000029900.6
      Conserved Domains (2) summary
      COG1527
      Location:14350
      NtpC; Archaeal/vacuolar-type H+-ATPase subunit C/Vma6 [Energy production and conversion]
      pfam01992
      Location:16338
      vATP-synt_AC39; ATP synthase (C/AC39) subunit

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      19876838..19922566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320194.3XP_017175683.1  V-type proton ATPase subunit d 2 isoform X1

      Conserved Domains (1) summary
      pfam01992
      Location:1234
      vATP-synt_AC39; ATP synthase (C/AC39) subunit