PTGDR2 prostaglandin D2 receptor 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PTGDR2provided by HGNC
Official Full Name: prostaglandin D2 receptor 2provided by HGNC
Primary source: HGNC:HGNC:4502
See related: Ensembl:ENSG00000183134 MIM:604837; AllianceGenome:HGNC:4502
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DP2; DL1R; CD294; CRTH2; GPR44
Summary: This gene encodes a G-protein-coupled receptor that is preferentially expressed in CD4+ effector T helper 2 (Th2) cells. This protein is a prostaglandin D2 receptor that mediates the pro-inflammatory chemotaxis of eosinophils, basophils, and Th2 lymphocytes generated during allergic inflammation. Single nucleotide polymorphisms in the 3' UTR of this gene have been associated with asthma susceptibility.[provided by RefSeq, Mar 2011]
Expression: Broad expression in stomach (RPKM 4.7), colon (RPKM 3.6) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q12.2

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (60850933..60855950, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (60802052..60807069, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (60618406..60623423, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

High PGD2 receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model.
Title: High PGD(2) receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model.
Molecular basis for lipid recognition by the prostaglandin D2 receptor CRTH2.
Title: Molecular basis for lipid recognition by the prostaglandin D(2) receptor CRTH2.
YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2.
Title: YAP promotes self-renewal of gastric cancer cells by inhibiting expression of L-PTGDS and PTGDR2.
A Granulocytic Signature Identifies COVID-19 and Its Severity.
Title: A Granulocytic Signature Identifies COVID-19 and Its Severity.
Knockdown of the DP2 receptor in cultured human hair follicles inhibits the anagen-catagen transition. outer root sheath and dermal papilla cells express higher levels of DP2 receptor compared with the matched nonbalding cells of male pattern baldness patients.
Title: Expression Level of Prostaglandin D2 Receptor 2 Regulates Hair Regression.
We did not find differences in PTGDR2 in affected and unaffected individuals.
Title: Prostaglandins in androgenetic alopecia in 12 men and four female.
the beneficial effects of DP2 blockade or DP1 agonism were associated with increased interferon-lambda (IFN-lambda) [interleukin-28A/B (IL-28A/B)] expression and were lost upon IL-28A neutralization.
Title: PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production.
These results demonstrate the critical role of CRTH2-mediated Th2 response in Pulmonary arterial hypertension pathogenesis.
Title: Inhibition of CRTH2-mediated Th2 activation attenuates pulmonary hypertension in mice.
The structures, together with docking and ligand-binding data, reveal a semi-occluded pocket covered by a well-structured amino terminus and different binding modes of chemically diverse CRTH2 antagonists
Title: Structures of the Human PGD(2) Receptor CRTH2 Reveal Novel Mechanisms for Ligand Recognition.
Prostaglandin D2 (PGD2) is a lipid mediator, predominantly released from mast cells, but also by other immune cells such as TH2 cells and dendritic cells, which plays a significant role in the pathophysiology of asthma
Title: The prostaglandin D(2) receptor 2 pathway in asthma: a key player in airway inflammation.

Submit: New GeneRIF Correction See all GeneRIFs (65)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:480585

RH11821 (e-PCR)
- UniSTS:42942

RH67900 (e-PCR)
- UniSTS:86731

IB1021 (e-PCR)
- UniSTS:47829

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin D receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin F receptor activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin J receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in immune response	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of male germ cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: prostaglandin D2 receptor 2

Names: G-protein coupled receptor 44; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; chemoattractant receptor-homologous molecule expressed on TH2 cells; putative G-protein coupled receptor 44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.