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    Psmd4 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83499, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Psmd4provided by RGD
    Official Full Name
    proteasome 26S subunit ubiquitin receptor, non-ATPase 4provided by RGD
    Primary source
    RGD:621109
    See related
    Ensembl:ENSRNOG00000021042 AllianceGenome:RGD:621109
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytoplasm. Orthologous to human PSMD4 (proteasome 26S subunit ubiquitin receptor, non-ATPase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Muscle (RPKM 474.1), Heart (RPKM 414.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185287941..185297238, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182598934..182608250, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196198303..196207569, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase beta Neighboring gene uncharacterized LOC102547008 Neighboring gene zinc finger protein 687 Neighboring gene uncharacterized LOC134485649 Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons. Huang Q, et al. J Biol Chem, 2013 Apr 26. PMID 23508964, Free PMC Article
    2. Distribution and immunoregulatory properties of antisecretory factor. Davidson TS, et al. Lab Invest, 2004 Mar. PMID 14767482
    3. Molecular cloning and expression of rat antisecretory factor and its intracellular localization. Tateishi K, et al. Biochem Cell Biol, 1999. PMID 10505793
    4. [Expression of antisecretory factor and aquaporin 1, 2 in the rat inner ear and their interaction]. Li MN, et al. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 2007 Apr. PMID 17628981
    5. The interaction of angiocidin with tissue transglutaminase. L'Heureux DZ, et al. Exp Mol Pathol, 2010 Feb. PMID 19931242, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons.
      Title: Negative regulation of 26S proteasome stability via calpain-mediated cleavage of Rpn10 subunit upon mitochondrial dysfunction in neurons.
    2. Antisecretory factor was widely distributed in the inner ear. Interaction between AQP1, AQP2 and AF might be possible.
      Title: [Expression of antisecretory factor and aquaporin 1, 2 in the rat inner ear and their interaction].
    3. data suggest that antisecretory factor may have a previously unsuspected role in regulating the immune system
      Title: Distribution and immunoregulatory properties of antisecretory factor.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyubiquitin modification-dependent protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fluid transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome accessory complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    26S proteasome non-ATPase regulatory subunit 4
    Names
    antisecretory factor
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
    proteasome 26S subunit, non-ATPase 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031331.1 → NP_112621.1  26S proteasome non-ATPase regulatory subunit 4

      See identical proteins and their annotated locations for NP_112621.1

      Status: PROVISIONAL

      Source sequence(s)
      AB017188
      UniProtKB/TrEMBL
      A0A8I6A4A3, A6K2U1, F7FEE4, O88321
      Related
      ENSRNOP00000028589.1, ENSRNOT00000028589.5
      Conserved Domains (2) summary
      cd01452
      Location:1 → 187
      VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
      cd22297
      Location:324 → 366
      PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      185287941..185297238 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006232924.5 → XP_006232986.1  26S proteasome non-ATPase regulatory subunit 4 isoform X1

      See identical proteins and their annotated locations for XP_006232986.1

      UniProtKB/TrEMBL
      A0A8I6A4A3, Q9ESH1
      Conserved Domains (2) summary
      cd01452
      Location:1 → 187
      VWA_26S_proteasome_subunit; 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of ...
      cd22297
      Location:321 → 363
      PSMD4_RAZUL; RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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