Cox4i1 cytochrome c oxidase subunit 4i1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cox4i1provided by RGD
Official Full Name: cytochrome c oxidase subunit 4i1provided by RGD
Primary source: RGD:68374
See related: AllianceGenome:RGD:68374
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cox4; Cox4a
Summary: Predicted to enable oxidoreductase activity. Involved in response to nutrient. Predicted to be located in cytosol; mitochondrial inner membrane; and nucleoplasm. Predicted to be part of mitochondrial respiratory chain complex IV. Biomarker of protein-energy malnutrition. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COX4I1 (cytochrome c oxidase subunit 4I1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 7845.6), Muscle (RPKM 4333.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (65630383..65636623)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (48721680..48727920)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (54245958..54252198)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The results provided in this communication indicate that a multi-protein ribonucleoprotein complex is formed in association with the COXIV 38 nt zipcode.
Title: Molecular determinants of cytochrome C oxidase IV mRNA axonal trafficking.
Data show that microRNA-338 (miR-338) modulation of local cytochrome c oxidase IV (COXIV) and ATP synthase subunit 9 (ATP5G1) expression has a marked effect on axonal reactive oxygen species levels, as well as axonal growth.
Title: MicroRNA-338 regulates the axonal expression of multiple nuclear-encoded mitochondrial mRNAs encoding subunits of the oxidative phosphorylation machinery.
COX IV in the hippocampus increased 10h after exercise and remained elevated for 24h postexercise.
Title: Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins.
Data show that phenylephrine induced elevation of homocysteine restricts COPPER (Cu) availability through its interaction with Cu and suppression of Cu chaperones, leading to the decrease in cytochrome c oxidase (CCO) activity.
Title: Homocysteine restricts copper availability leading to suppression of cytochrome C oxidase activity in phenylephrine-treated cardiomyocytes.
The expression of COX I and COX IV proteins during hypoxic exposure is coordinately regulated by post-transcriptional mechanisms.
Title: [Effects of hypoxic exposure on coordinative expression of cytochrome oxidase subunits I and IV in rat cerebral cortex].
Results suggest that damage to cytochrome c oxidase (CcO) and dissociation of respirosome complexes are critical factors in alcohol-induced toxicity, which is augmented by mitochondrion-targeted cytochrome CYP2E1.
Title: Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes.
cytochrome C oxidase was higher during the light period than during the dark period.
Title: Circadian rhythm of metabolic oscillation in suprachiasmatic nucleus depends on the mitochondrial oxidation state, reflected by cytochrome C oxidase and lactate dehydrogenase.
Report loss of Cox4 subunits in ischemia-reperfusion injury and exacerbation of subunit loss by PKC-epsilon inhibition.
Title: Differential loss of cytochrome-c oxidase subunits in ischemia-reperfusion injury: exacerbation of COI subunit loss by PKC-epsilon inhibition.
Oxidation of 10-formyltetrahydrofolate to 10-formyldihydrofolate by complex IV in the mitochondrial intermembrane space represents a previously unidentified folate metabolic pathway.
Title: Oxidation of 10-formyltetrahydrofolate to 10-formyldihydrofolate by complex IV of rat mitochondria.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH127425 (e-PCR)
- UniSTS:210735

RH125550 (e-PCR)
- UniSTS:162364

Cox4a (e-PCR), detects polymorphism
- UniSTS:141379

Cox4a (e-PCR), detects polymorphism
- UniSTS:141380

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, cytochrome c to oxygen	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, cytochrome c to oxygen	IEA Inferred from Electronic Annotation more info
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex IV	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex IV	IEA Inferred from Electronic Annotation more info
part_of mitochondrial respiratory chain complex IV	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Names: COX IV-1; cytochrome c oxidase polypeptide IV; cytochrome c oxidase, subunit 4a; cytochrome c oxidase, subunit IV; cytochrome c oxidase, subunit IVa

NP_058898.1

EC 7.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017202.1 → NP_058898.1 cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_058898.1

Status: PROVISIONAL

Source sequence(s)

X54081

UniProtKB/Swiss-Prot

P10888

UniProtKB/TrEMBL

A0A8L2QCS6, A6IZM8

Conserved Domains (1) summary

pfam02936
Location:36 → 168

COX4; Cytochrome c oxidase subunit IV