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    Trdmt1 tRNA aspartic acid methyltransferase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291324, updated on 2-May-2024

    Summary

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    Official Symbol
    Trdmt1provided by RGD
    Official Full Name
    tRNA aspartic acid methyltransferase 1provided by RGD
    Primary source
    RGD:1306292
    See related
    Ensembl:ENSRNOG00000026132 AllianceGenome:RGD:1306292
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Dnmt2
    Summary
    Predicted to enable tRNA (cytosine-5-)-methyltransferase activity. Involved in response to amphetamine. Predicted to be located in cytoplasm. Orthologous to human TRDMT1 (tRNA aspartic acid methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 89.6), Thymus (RPKM 88.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    17q12.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (81510740..81554036, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (76601966..76646104, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (80824652..80859585, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene Ras suppressor protein 1 Neighboring gene uncharacterized LOC134482610 Neighboring gene cubilin Neighboring gene uncharacterized LOC102550536 Neighboring gene vimentin Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-α pathway. Li Z, et al. Animal Model Exp Med, 2022 Apr. PMID 35474613, Free PMC Article
    2. Psychostimulant alters expression of DNA methyltransferase mRNA in the rat brain. Numachi Y, et al. Ann N Y Acad Sci, 2004 Oct. PMID 15542706
    3. Human DNMT2 methylates tRNA(Asp) molecules using a DNA methyltransferase-like catalytic mechanism. Jurkowski TP, et al. RNA, 2008 Aug. PMID 18567810, Free PMC Article
    4. The human Dnmt2 has residual DNA-(cytosine-C5) methyltransferase activity. Hermann A, et al. J Biol Chem, 2003 Aug 22. PMID 12794065
    5. RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis. Tuorto F, et al. Nat Struct Mol Biol, 2012 Sep. PMID 22885326

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-kappaB/MAPK-TNF-alpha pathway.
      Title: TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-α pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112666

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-5-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tRNA (cytidine-5-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables tRNA methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to amphetamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA methylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA stabilization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tRNA (cytosine(38)-C(5))-methyltransferase
    Names
    DNA (cytosine-5)-methyltransferase-like protein 2
    DNA methyltransferase 2
    tRNA (cytosine-5-)-methyltransferase
    NP_001026813.1
    XP_063132319.1
    XP_063132320.1
    XP_063132321.1
    XP_063132322.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031643.1 → NP_001026813.1  tRNA (cytosine(38)-C(5))-methyltransferase

      See identical proteins and their annotated locations for NP_001026813.1

      Status: PROVISIONAL

      Source sequence(s)
      BC098700
      UniProtKB/Swiss-Prot
      Q4G073
      UniProtKB/TrEMBL
      A0A8I5YBX0, A6JM42
      Related
      ENSRNOP00000038279.4, ENSRNOT00000038651.6
      Conserved Domains (1) summary
      cd00315
      Location:4 → 391
      Cyt_C5_DNA_methylase; Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      81510740..81554036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276250.1 → XP_063132320.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X2

    2. XM_063276251.1 → XP_063132321.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X3

    3. XM_063276249.1 → XP_063132319.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X1

    4. XM_063276252.1 → XP_063132322.1  tRNA (cytosine(38)-C(5))-methyltransferase isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4G073.1 GenPept UniProtKB/Swiss-Prot:Q4G073

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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