Sla2 Src-like-adaptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sla2provided by MGI
Official Full Name: Src-like-adaptor 2provided by MGI
Primary source: MGI:MGI:1925049
See related: Ensembl:ENSMUSG00000027636 AllianceGenome:MGI:1925049
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SLAP2; SLAP-2; A930009E21Rik
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity; protein N-terminus binding activity; and signaling adaptor activity. Acts upstream of or within T cell activation. Located in late endosome and plasma membrane. Is expressed in thymus primordium. Orthologous to human SLA2 (Src like adaptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 36.8), placenta adult (RPKM 10.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H1; 2 77.89 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (156716071..156729161, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (156874151..156887250, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex.
Title: Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL-SLAP2 crystal complex.
SLAP2 acts as a negative regulator of FLT3 signaling and therefore, modulation of SLAP2 expression levels may provide an alternative therapeutic approach for FLT3-ITD positive acute myeloid leukemia
Title: Src-like adaptor protein 2 (SLAP2) binds to and inhibits FLT3 signaling.
SLAP and SLAP2 are critical inhibitors of platelet (hem)ITAM signaling in the setting of arterial thrombosis and ischemic stroke
Title: SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice.
In bone marrow-derived dendritic cells lacking SLAP and closely related SLAP2, downregulation of the granulocyte-macrophage colony-stimulating factor (GM-CSF)beta receptor is impaired.
Title: The Src-like adaptor protein regulates GM-CSFR signaling and monocytic dendritic cell maturation.
SLAP-2 plays a role in c-Cbl-dependent down-regulation of CSF-1R signaling
Title: The Src-like adaptor protein 2 regulates colony-stimulating factor-1 receptor signaling and down-regulation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129504 (e-PCR)
- UniSTS:212808

AI430952 (e-PCR)
- UniSTS:165227

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of T cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: src-like-adapter 2

Names: modulator of antigen receptor signaling MARS; src-like adapter protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356495.1 → NP_001343424.1 src-like-adapter 2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AL935150, BC052655

Consensus CDS

CCDS38302.1

UniProtKB/Swiss-Prot

Q3UU74, Q8C0K2, Q8R4L0, Q8VI42, Q9D1Z9

UniProtKB/TrEMBL

Q7TMX7

Related

ENSMUSP00000105189.4, ENSMUST00000109561.4

Conserved Domains (2) summary

cd10344
Location:82 → 185

SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins

cl17036
Location:35 → 89

SH3; Src Homology 3 domain superfamily
NM_029983.6 → NP_084259.1 src-like-adapter 2

See identical proteins and their annotated locations for NP_084259.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AK138709, AL935150

Consensus CDS

CCDS38302.1

UniProtKB/Swiss-Prot

Q3UU74, Q8C0K2, Q8R4L0, Q8VI42, Q9D1Z9

UniProtKB/TrEMBL

Q7TMX7

Related

ENSMUSP00000029164.3, ENSMUST00000029164.9

Conserved Domains (2) summary

cd10344
Location:82 → 185

SH2_SLAP; Src homology 2 domain found in Src-like adaptor proteins

cl17036
Location:35 → 89

SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

156716071..156729161 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239846.1 → XP_011238148.1 src-like-adapter 2 isoform X1

See identical proteins and their annotated locations for XP_011238148.1

UniProtKB/TrEMBL

Q7TMX7

Conserved Domains (2) summary

cl15255
Location:82 → 200

SH2; Src homology 2 (SH2) domain

cl17036
Location:35 → 89

SH3; Src Homology 3 domain superfamily
XM_011239845.3 → XP_011238147.1 src-like-adapter 2 isoform X1

See identical proteins and their annotated locations for XP_011238147.1

UniProtKB/TrEMBL

Q7TMX7

Conserved Domains (2) summary

cl15255
Location:82 → 200

SH2; Src homology 2 (SH2) domain

cl17036
Location:35 → 89

SH3; Src Homology 3 domain superfamily