Rgs9 regulator of G-protein signaling 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rgs9provided by MGI
Official Full Name: regulator of G-protein signaling 9provided by MGI
Primary source: MGI:MGI:1338824
See related: Ensembl:ENSMUSG00000020599 AllianceGenome:MGI:1338824
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RGS9-1; Rgs9-2
Summary: Predicted to enable GTPase activator activity. Acts upstream of or within dark adaptation and light adaption. Located in several cellular components, including glutamatergic synapse; photoreceptor inner segment; and postsynaptic density membrane. Is expressed in several structures, including central nervous system and retina. Human ortholog(s) of this gene implicated in bradyopsia. Orthologous to human RGS9 (regulator of G protein signaling 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 4.9), genital fat pad adult (RPKM 4.6) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E1; 11 71.86 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (109116174..109189013, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (109225348..109298181, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ablation of RGS9-2 in cultured striatal neurons reduced calcium influx thru NMDARs. Mice lacking RGS9-2 displayed behavioral hypersensitivity to NMDAR blockade.These changes were selective to D2-medium spiny neurons, increasing the frequency of mEPSC and inhibiting paired-pulse ratio.mediated by the NMDAR-dependent inhibition of D2-MSN retrograde endocannabinoid signaling to CB1 receptor on presynaptic terminals.
Title: Selective Role of RGS9-2 in Regulating Retrograde Synaptic Signaling of Indirect Pathway Medium Spiny Neurons in Dorsal Striatum.
The authors show that genetic depletion of RGS9-2 mimics the D2 receptor loss of DYT1 dystonia striatum, whereas RGS9-2 overexpression rescues both receptor levels and electrophysiological responses in Dyt1 striatal neurons.
Title: RGS9-2 rescues dopamine D2 receptor levels and signaling in DYT1 dystonia mouse models.
Association with the plasma membrane is sufficient for potentiating catalytic activity of RGS7 and RGS9-2 proteins.
Title: Association with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily.
Data show that the regulator of G-protein signaling 9-2 (RGS9-2) in the nucleus accumbens (NAc) affects the expression of many genes known to be involved in nociception, analgesia, and antidepressant drug actions.
Title: RGS9-2--controlled adaptations in the striatum determine the onset of action and efficacy of antidepressants in neuropathic pain states.
role in sensory and mood related symptoms of neuropathic pain
Title: RGS9-2 modulates sensory and mood related symptoms of neuropathic pain.
gene regulation in the Striatum of RGS9-deficient mice
Title: Adaptive gene regulation in the Striatum of RGS9-deficient mice.
The complex of G protein regulator RGS9-2 and Gbeta(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum.
Title: The complex of G protein regulator RGS9-2 and Gβ(5) controls sensitization and signaling kinetics of type 5 adenylyl cyclase in the striatum.
The expression of RGS9 in two distinct populations of neural precursor cells demonstrates that RGS9 and its accessory proteins may play an important role in neuronal development.
Title: Regulator of G protein signaling 9-2 (RGS9-2) mRNA is up regulated during neuronal differentiation of mouse embryonic stem cells.
RGS9 knockout causes a short delay in light responses of ON-bipolar cells.
Title: RGS9 knockout causes a short delay in light responses of ON-bipolar cells.
These studies with humans, rats and mice implicate RGS9-2 as a factor in regulating body weight.
Title: Association between regulator of G protein signaling 9-2 and body weight.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-31f3 (e-PCR)
- UniSTS:257585

AF011358 (e-PCR)
- UniSTS:185922

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

D11Mit180 (e-PCR), detects polymorphism
- UniSTS:126375

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within dark adaptation	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within light adaption	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 9

Names: ROS GAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001165934.1 → NP_001159406.1 regulator of G-protein signaling 9 isoform 2

See identical proteins and their annotated locations for NP_001159406.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK138159, AL604043, BG298879, BY277335

Consensus CDS

CCDS48969.1

UniProtKB/TrEMBL

Q3UUR0

Related

ENSMUSP00000102317.2, ENSMUST00000106706.8

Conserved Domains (3) summary

smart00224
Location:219 → 280

GGL; G protein gamma subunit-like motifs

cd08739
Location:292 → 412

RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein

cd04450
Location:22 → 109

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...
NM_011268.2 → NP_035398.2 regulator of G-protein signaling 9 isoform 1

See identical proteins and their annotated locations for NP_035398.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL604043

Consensus CDS

CCDS25576.1

UniProtKB/Swiss-Prot

A1L352, O54828, Q9Z0S0

Related

ENSMUSP00000020920.4, ENSMUST00000020920.10

Conserved Domains (3) summary

smart00224
Location:219 → 280

GGL; G protein gamma subunit-like motifs

cd08739
Location:292 → 412

RGS_RGS9; Regulator of G protein signaling (RGS) domain found in the RGS9 protein

cd04450
Location:22 → 109

DEP_RGS7-like; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in RGS (regulator of G-protein signaling) proteins of the subfamily R7. This subgroup contains RGS7, RGS6, RGS9 and RGS11. They share a common domain architecture, containing, beside the RGS domain, ...