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    Mettl27 methyltransferase like 27 [ Mus musculus (house mouse) ]

    Gene ID: 79565, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Mettl27provided by MGI
    Official Full Name
    methyltransferase like 27provided by MGI
    Primary source
    MGI:MGI:1933146
    See related
    Ensembl:ENSMUSG00000040557 AllianceGenome:MGI:1933146
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Wbscr27
    Summary
    Predicted to enable methyltransferase activity. Orthologous to human METTL27 (methyltransferase like 27). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bladder adult (RPKM 16.2), genital fat pad adult (RPKM 9.5) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl27 in Genome Data Viewer
    Location:
    5 G2; 5 74.89 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134961158..134971491)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134932304..134942637)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 270 Neighboring gene claudin 13 Neighboring gene STARR-seq mESC enhancer starr_14554 Neighboring gene RIKEN cDNA 9030607J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1310 Neighboring gene STARR-seq mESC enhancer starr_14556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135417798-135418057 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135427401-135427609 Neighboring gene claudin 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135442157-135442340 Neighboring gene STARR-seq mESC enhancer starr_14561 Neighboring gene Williams Beuren syndrome chromosome region 25 (human) Neighboring gene claudin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells. Kole C, et al. PLoS One, 2016. PMID 26985665, Free PMC Article
    2. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. DeSilva U, et al. Genome Res, 2002 Jan. PMID 11779826, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC8159

    General protein information

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    Preferred Names
    methyltransferase-like protein 27
    Names
    Williams Beuren syndrome chromosome region 27
    Williams-Beuren syndrome chromosome region 27 homolog

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347490.1 → NP_001334419.1  methyltransferase-like protein 27 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
      Source sequence(s)
      AC079938
      Consensus CDS
      CCDS84970.1
      UniProtKB/TrEMBL
      Q3V1G0, Q8BY07
      Related
      ENSMUSP00000106852.3, ENSMUST00000111221.9
      Conserved Domains (2) summary
      COG4976
      Location:30 → 115
      COG4976; Predicted methyltransferase, contains TPR repeat [General function prediction only]
      pfam13649
      Location:71 → 109
      Methyltransf_25; Methyltransferase domain

    2. NM_001359535.1 → NP_001346464.1  methyltransferase-like protein 27 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AC079938, FO717931
      Consensus CDS
      CCDS19727.1
      UniProtKB/TrEMBL
      Q3V1G0, Q8BGM4
      Related
      ENSMUSP00000106849.2, ENSMUST00000111218.8
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 162
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:29 → 109
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. NM_001359536.1 → NP_001346465.1  methyltransferase-like protein 27 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AC079938, AY354926
      Consensus CDS
      CCDS19727.1
      UniProtKB/TrEMBL
      Q3V1G0, Q8BGM4
      Related
      ENSMUSP00000106850.2, ENSMUST00000111219.8
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 162
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:29 → 109
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. NM_001359537.1 → NP_001346466.1  methyltransferase-like protein 27 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AC079938
      Consensus CDS
      CCDS19727.1
      UniProtKB/TrEMBL
      Q3V1G0, Q8BGM4
      Related
      ENSMUSP00000144170.2, ENSMUST00000201847.3
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 162
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:29 → 109
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. NM_001359538.1 → NP_001346467.1  methyltransferase-like protein 27 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
      Source sequence(s)
      AC079938, AK042578
      Consensus CDS
      CCDS84970.1
      UniProtKB/TrEMBL
      Q3V1G0, Q8BY07
      Related
      ENSMUSP00000067814.6, ENSMUST00000068617.12
      Conserved Domains (2) summary
      COG4976
      Location:30 → 115
      COG4976; Predicted methyltransferase, contains TPR repeat [General function prediction only]
      pfam13649
      Location:71 → 109
      Methyltransf_25; Methyltransferase domain

    6. NM_001425731.1 → NP_001412660.1  methyltransferase-like protein 27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079938
      UniProtKB/TrEMBL
      Q8BY07

    7. NM_001425732.1 → NP_001412661.1  methyltransferase-like protein 27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079938
      UniProtKB/TrEMBL
      Q8BY07

    8. NM_001425733.1 → NP_001412662.1  methyltransferase-like protein 27 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC079938
      UniProtKB/TrEMBL
      Q8BY07

    9. NM_001425734.1 → NP_001412663.1  methyltransferase-like protein 27 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC079938
      UniProtKB/TrEMBL
      Q8BGM4

    10. NM_024479.2 → NP_077799.2  methyltransferase-like protein 27 isoform 1

      See identical proteins and their annotated locations for NP_077799.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
      Source sequence(s)
      AY354925
      Consensus CDS
      CCDS19727.1
      UniProtKB/TrEMBL
      Q3V1G0, Q8BGM4
      Related
      ENSMUSP00000039080.8, ENSMUST00000047196.14
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 162
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:29 → 109
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      134961158..134971491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504522.4 → XP_006504585.1  methyltransferase-like protein 27 isoform X1

      See identical proteins and their annotated locations for XP_006504585.1

      UniProtKB/TrEMBL
      Q3V1G0
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 161
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:31 → 103
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_006504528.4 → XP_006504591.1  methyltransferase-like protein 27 isoform X1

      See identical proteins and their annotated locations for XP_006504591.1

      UniProtKB/TrEMBL
      Q3V1G0
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 161
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:31 → 103
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    3. XM_006504527.4 → XP_006504590.1  methyltransferase-like protein 27 isoform X1

      See identical proteins and their annotated locations for XP_006504590.1

      UniProtKB/TrEMBL
      Q3V1G0
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 161
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:31 → 103
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_006504529.4 → XP_006504592.1  methyltransferase-like protein 27 isoform X1

      See identical proteins and their annotated locations for XP_006504592.1

      UniProtKB/TrEMBL
      Q3V1G0
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 161
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:31 → 103
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_006504524.5 → XP_006504587.1  methyltransferase-like protein 27 isoform X1

      See identical proteins and their annotated locations for XP_006504587.1

      UniProtKB/TrEMBL
      Q3V1G0
      Conserved Domains (2) summary
      pfam13649
      Location:71 → 161
      Methyltransf_25; Methyltransferase domain
      cl17173
      Location:31 → 103
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version

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