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    Pgbd5 piggyBac transposable element derived 5 [ Mus musculus (house mouse) ]

    Gene ID: 209966, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Pgbd5provided by MGI
    Official Full Name
    piggyBac transposable element derived 5provided by MGI
    Primary source
    MGI:MGI:2429955
    See related
    Ensembl:ENSMUSG00000050751 AllianceGenome:MGI:2429955
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900019M05Rik
    Summary
    The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in cortex adult (RPKM 40.9), frontal lobe adult (RPKM 35.4) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    8 E2; 8 72.65 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (125095788..125161230, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (124369049..124433936, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_22999 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 2 Neighboring gene predicted gene, 24459 Neighboring gene STARR-seq mESC enhancer starr_23006 Neighboring gene RIKEN cDNA C330016L05 gene Neighboring gene predicted gene, 30209

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PGBD5: a neural-specific intron-containing piggyBac transposase domesticated over 500 million years ago and conserved from cephalochordates to humans. Pavelitz T, et al. Mob DNA, 2013 Nov 1. PMID 24180413, Free PMC Article
    2. Molecular evolutionary analysis of the widespread piggyBac transposon family and related "domesticated" sequences. Sarkar A, et al. Mol Genet Genomics, 2003 Nov. PMID 12955498
    3. Trim33 Binds and Silences a Class of Young Endogenous Retroviruses in the Mouse Testis; a Novel Component of the Arms Race between Retrotransposons and the Host Genome. Isbel L, et al. PLoS Genet, 2015 Dec. PMID 26624618, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway.
      Title: Knockdown of PGBD5 inhibits the malignant progression of glioma through upregulation of the PPAR pathway.
    2. Childhood cancer mutagenesis caused by transposase-derived PGBD5.
      Title: Childhood cancer mutagenesis caused by transposase-derived PGBD5.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transposase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transposase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in non-replicative DNA transposition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-replicative DNA transposition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within transposition IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    piggyBac transposable element-derived protein 5
    Names
    piggyBac transposase 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_171824.3 → NP_741958.2  piggyBac transposable element-derived protein 5

      Status: VALIDATED

      Source sequence(s)
      AC114005, AC126930
      Consensus CDS
      CCDS22770.1
      UniProtKB/Swiss-Prot
      D3YZI9, D3Z077, E9PUA8, Q52KE6
      Related
      ENSMUSP00000120984.2, ENSMUST00000140012.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      125095788..125161230 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243379.2 → XP_030099239.1  piggyBac transposable element-derived protein 5 isoform X1

      UniProtKB/TrEMBL
      A0A510C1L5
      Related
      ENSMUSP00000133560.2, ENSMUST00000172566.8
      Conserved Domains (1) summary
      pfam13843
      Location:20 → 386
      DDE_Tnp_1_7; Transposase IS4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3YZI9.1 GenPept UniProtKB/Swiss-Prot:D3YZI9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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