Uvrag UV radiation resistance associated gene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uvragprovided by MGI
Official Full Name: UV radiation resistance associated geneprovided by MGI
Primary source: MGI:MGI:1925860
See related: Ensembl:ENSMUSG00000035354 AllianceGenome:MGI:1925860
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Uvrag1; Uvragl; 9530039D02Rik
Summary: Enables SH3 domain binding activity and SNARE binding activity. Involved in DNA repair; chromosome segregation; and microtubule cytoskeleton organization. Acts upstream of or within SNARE complex assembly and viral entry into host cell. Located in phagocytic vesicle. Part of protein-containing complex. Is expressed in midgut; smooth muscle tissue; and thyroid gland. Orthologous to human UVRAG (UV radiation resistance associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in spleen adult (RPKM 13.8), thymus adult (RPKM 12.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E1; 7 53.92 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (98535949..98790373, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (98886742..99141167, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis.
Title: Distinct roles of UVRAG and EGFR signaling in skeletal muscle homeostasis.
UVRAG in autophagy, inflammation, and cancer.
Title: UVRAG in autophagy, inflammation, and cancer.
UVRAG is a crucial autophagy regulator in vivo, and autophagy promotion may help prevent/treat inflammatory disease and cancer in susceptible individuals.
Title: A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice.
Collectively, these data suggest that UVRAG deficiency exacerbates doxorubicin-induced cardiotoxicity, at least in part, through aggravation of doxorubicin-induced impaired autophagic flux.
Title: UVRAG Deficiency Exacerbates Doxorubicin-Induced Cardiotoxicity.
UVRAG is a regulator of CRL4(DDB2)-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition.
Title: Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase.
Beclin 1 regulates endosome pathways via the UVRAG-VPS34 complex.
Title: Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.
EWSR1 is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
Title: Uvrag targeting by Mir125a and Mir351 modulates autophagy associated with Ewsr1 deficiency.
tubulation requires mTOR activity, and we identified two direct mTOR phosphorylation sites on UVRAG (S550 and S571) that activate VPS34.
Title: mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.
silencing of UVRAG significantly attenuated the antimicrobial effects of macrophages against M. tuberculosis.
Title: MicroRNA-125a Inhibits Autophagy Activation and Antimicrobial Responses during Mycobacterial Infection.
data provide novel insights into the control of autophagy in T cells and identify UVRAG as a new regulator of naive peripheral T-cell homeostasis.
Title: Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Transposon induced (1) 1 citation
Targeted (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI648770 (e-PCR)
- UniSTS:164363

RH136062 (e-PCR)
- UniSTS:210057

D1S3694 (e-PCR)
- UniSTS:474272

D7Mit354 (e-PCR), detects polymorphism
- UniSTS:131253

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA repair	ISO Inferred from Sequence Orthology more info
involved_in SNARE complex assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within SNARE complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in autophagy	ISO Inferred from Sequence Orthology more info
involved_in centrosome cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in centrosome cycle	ISO Inferred from Sequence Orthology more info
involved_in chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in double-strand break repair via classical nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in maintenance of Golgi location	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in receptor catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within symbiont entry into host cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA-dependent protein kinase complex	ISO Inferred from Sequence Orthology more info
located_in autophagosome membrane	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
is_active_in lytic vacuole	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	IPI Inferred from Physical Interaction more info	PubMed
part_of phosphatidylinositol 3-kinase complex, class III	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: UV radiation resistance-associated protein

Names: UV radiation resistance associated protein; UV radiation resistance-associated gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178635.3 → NP_848750.3 UV radiation resistance-associated protein

See identical proteins and their annotated locations for NP_848750.3

Status: VALIDATED

Source sequence(s)

AK030814, AK078085, BB530952, BY024873

Consensus CDS

CCDS21476.1

UniProtKB/Swiss-Prot

Q8BVI8, Q8C0K8, Q8K245

UniProtKB/TrEMBL

Q8BXW8

Related

ENSMUSP00000045297.9, ENSMUST00000037968.10

Conserved Domains (2) summary

cd00030
Location:44 → 118

C2; C2 domain

pfam10186
Location:183 → 441

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

98535949..98790373 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508349.4 → XP_006508412.1 UV radiation resistance-associated protein isoform X1

UniProtKB/TrEMBL

Q8BXW8

Conserved Domains (1) summary

pfam10186
Location:140 → 398

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
XM_030243116.2 → XP_030098976.1 UV radiation resistance-associated protein isoform X2

Conserved Domains (1) summary

pfam10186
Location:4 → 173

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14
XM_036153589.1 → XP_036009482.1 UV radiation resistance-associated protein isoform X2

Conserved Domains (1) summary

pfam10186
Location:4 → 173

Atg14; Vacuolar sorting 38 and autophagy-related subunit 14