Dus4l dihydrouridine synthase 4 like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dus4lprovided by MGI
Official Full Name: dihydrouridine synthase 4 likeprovided by MGI
Primary source: MGI:MGI:1919166
See related: Ensembl:ENSMUSG00000020648 AllianceGenome:MGI:1919166
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pp35; 2310069P03Rik; 2700089B10Rik
Summary: Predicted to enable tRNA dihydrouridine synthase activity. Predicted to act upstream of or within tRNA processing. Orthologous to human DUS4L (dihydrouridine synthase 4 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 2.9), limb E14.5 (RPKM 2.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A3; 12 13.68 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (31690049..31704834, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (31640050..31654866, complement)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236824

NoName (e-PCR)
- UniSTS:236825

NoName (e-PCR)
- UniSTS:488858

AI482040 (e-PCR)
- UniSTS:165815

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables tRNA dihydrouridine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tRNA-dihydrouridine20a synthase activity	IEA Inferred from Electronic Annotation more info
enables tRNA-dihydrouridine20b synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tRNA dihydrouridine synthesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
involved_in tRNA processing	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like

NP_001404957.1

EC 1.3.1.90

NP_082278.1

EC 1.3.1.90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418028.1 → NP_001404957.1 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform 2

Status: VALIDATED

Source sequence(s)

AC119950
NM_028002.3 → NP_082278.1 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like isoform 1

See identical proteins and their annotated locations for NP_082278.1

Status: VALIDATED

Source sequence(s)

AC119950

Consensus CDS

CCDS25865.1

UniProtKB/Swiss-Prot

Q32M08, Q9D6P4

UniProtKB/TrEMBL

A0A0R4J016

Related

ENSMUSP00000020977.3, ENSMUST00000020977.4

Conserved Domains (2) summary

COG0042
Location:32 → 311

DusA; tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]

cd02801
Location:28 → 257

DUS_like_FMN; Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also ...