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    Qrsl1 glutaminyl-tRNA amidotransferase subunit QRSL1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309911, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Qrsl1provided by RGD
    Official Full Name
    glutaminyl-tRNA amidotransferase subunit QRSL1provided by RGD
    Primary source
    RGD:1359490
    See related
    Ensembl:ENSRNOG00000026049 AllianceGenome:RGD:1359490
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity. Predicted to be involved in glutaminyl-tRNAGln biosynthesis via transamidation and mitochondrial translation. Predicted to act upstream of or within regulation of protein stability. Predicted to be part of glutamyl-tRNA(Gln) amidotransferase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 40. Orthologous to human QRSL1 (glutaminyl-tRNA amidotransferase subunit QRSL1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 113.9), Muscle (RPKM 69.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    20q13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (48939858..48964812, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (47357206..47382160, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (48855839..48881112, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555452 Neighboring gene uncharacterized LOC102555396 Neighboring gene uncharacterized LOC134483830 Neighboring gene nuclear speckle splicing regulatory protein 1, pseudogene 1 Neighboring gene reticulon 4 interacting protein 1 Neighboring gene crystallin beta-gamma domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glutamyl-tRNAGln amidotransferase is essential for mammalian mitochondrial translation in vivo. Echevarría L, et al. Biochem J, 2014 May 15. PMID 24579914
    2. Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. Nagao A, et al. Proc Natl Acad Sci U S A, 2009 Sep 22. PMID 19805282, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC105526

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutaminyl-tRNAGln biosynthesis via transamidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of glutamyl-tRNA(Gln) amidotransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of glutamyl-tRNA(Gln) amidotransferase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glutamyl-tRNA(Gln) amidotransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial
    Names
    QRSL1, glutaminyl-tRNA amidotransferase subunit A
    glu-AdT subunit A
    glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
    glutaminyl-tRNA synthase-like protein 1
    glutamyl-tRNA(Gln) amidotransferase subunit A homolog
    NP_001014056.1
    XP_063135257.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014034.2 → NP_001014056.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

      See identical proteins and their annotated locations for NP_001014056.1

      Status: VALIDATED

      Source sequence(s)
      BC089213, JAXUCZ010000020
      UniProtKB/Swiss-Prot
      Q5FWT5
      UniProtKB/TrEMBL
      A0A8I5ZPV2
      Related
      ENSRNOP00000018891.5, ENSRNOT00000018892.8
      Conserved Domains (2) summary
      PRK00012
      Location:13 → 492
      gatA; aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed
      PRK07488
      Location:5 → 493
      PRK07488; indole acetimide hydrolase; Validated

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      48939858..48964812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279187.1 → XP_063135257.1  glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWT5.1 GenPept UniProtKB/Swiss-Prot:Q5FWT5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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