Gpx2 glutathione peroxidase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gpx2provided by RGD
Official Full Name: glutathione peroxidase 2provided by RGD
Primary source: RGD:727780
See related: Ensembl:ENSRNOG00000055672 AllianceGenome:RGD:727780
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GPX-GI; GSHPx-2; GSHPx-GI
Summary: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract in rodents, is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Knockout studies in mice lacking this gene suggest a role for this isozyme in intestinal inflammation and colon cancer development. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 2 and X. [provided by RefSeq, Aug 2017]
Expression: Biased expression in Lung (RPKM 267.7), Uterus (RPKM 131.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q24

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (101226745..101230033, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (95493589..95496877, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (99839960..99843245, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
Title: Glutathione Peroxidase gpx1 to gpx8 Genes Expression in Experimental Brain Tumors Reveals Gender-Dependent Patterns.
Dietary Se-enriched A. bisporus protected against increase in ileum permeability and up-regulated GPx-1 and GPx-2 expression, selenoenzymes relevant to mitigating oxidative stress.
Title: Selenium-enriched Agaricus bisporus mushroom protects against increase in gut permeability ex vivo and up-regulates glutathione peroxidase 1 and 2 in hyperthermally-induced oxidative stress in rats.
Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis
Title: Expression of glutathione peroxidase 2 is associated with not only early hepatocarcinogenesis but also late stage metastasis.
Gpx2 is an overexpressed gene in rat breast cancers
Title: Gpx2 is an overexpressed gene in rat breast cancers induced by three different chemical carcinogens.
Selenoenzyme GPx-2 is predominantly expressed in the tissues of the gastrointestinal tract, such as the small intestine and colon.
Title: Activity of the glutathione peroxidase-2. Differences in the selenium-dependent expression between colon and small intestine.
Novel sites of Gpx2 expression were observed in colon lymphatic tissue.
Title: Novel sites of cytosolic glutathione peroxidase expression in colon.
The Swiss-Prot/TrEMBL Accession Number for glutathione peroxidase 2 is P83645.
Title: Selenium-dependent glutathione peroxidase-GI is a major glutathione peroxidase activity in the mucosal epithelium of rodent intestine.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables glutathione peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutathione peroxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info
enables phospholipid-hydroperoxide glutathione peroxidase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid-hydroperoxide glutathione peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within biological process involved in interaction with symbiont	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to selenium ion	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to symbiotic bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within temperature homeostasis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutathione peroxidase 2

Names: GPx-2; glutathione peroxidase-gastrointestinal; phospholipid hydroperoxide glutathione peroxidase GPX2

NP_899653.2

EC 1.11.1.12

EC 1.11.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183403.2 → NP_899653.2 glutathione peroxidase 2

Status: REVIEWED

Source sequence(s)

BG664050, BQ196565, CX570255

UniProtKB/Swiss-Prot

P83645

UniProtKB/TrEMBL

A0A0G2K278

Related

ENSRNOP00000072136.2, ENSRNOT00000080270.2

Conserved Domains (1) summary

cd00340
Location:7 → 182

GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...