Rgs12 regulator of G-protein signaling 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgs12provided by RGD
Official Full Name: regulator of G-protein signaling 12provided by RGD
Primary source: RGD:3564
See related: Ensembl:ENSRNOG00000030568 AllianceGenome:RGD:3564
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables G-protein alpha-subunit binding activity and GTPase activator activity. Involved in termination of G protein-coupled receptor signaling pathway. Located in several cellular components, including apical dendrite; cytosol; and neuronal cell body. Part of protein-containing complex. Colocalizes with synapse. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 244.3), Spleen (RPKM 65.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14q21

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (79940561..80048637, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (75715925..75824012, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (80975239..81069519, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology via targeting RGS12 signaling pathway.
Title: MicroRNA-204-5p reduction in rat hippocampus contributes to stress-induced pathology via targeting RGS12 signaling pathway.
RGS12 may play a critical, and receptor-selective, role in coordinating Ras-dependent signals that are required for promoting and/or maintaining neuronal differentiation.
Title: Selective role for RGS12 as a Ras/Raf/MEK scaffold in nerve growth factor-mediated differentiation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132578 (e-PCR)
- UniSTS:215861

RH131193 (e-PCR)
- UniSTS:214476

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G-protein alpha-subunit binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase regulator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of G protein-coupled receptor signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in termination of G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 12

Names: regulator of G-protein signalling 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019339.2 → NP_062212.2 regulator of G-protein signaling 12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

O08774, O88383

UniProtKB/TrEMBL

A6IK12, G3V9H1

Related

ENSRNOP00000047497.4, ENSRNOT00000045068.4

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:1188 → 1209

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd00992
Location:19 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1387

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

79940561..80048637 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039092337.2 → XP_038948265.1 regulator of G-protein signaling 12 isoform X1

UniProtKB/Swiss-Prot

O08774, O88383

UniProtKB/TrEMBL

D4AB55

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:1188 → 1209

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd00992
Location:19 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1387

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006251351.5 → XP_006251413.1 regulator of G-protein signaling 12 isoform X1

See identical proteins and their annotated locations for XP_006251413.1

UniProtKB/Swiss-Prot

O08774, O88383

UniProtKB/TrEMBL

D4AB55

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:1188 → 1209

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd00992
Location:19 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1387

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006251352.5 → XP_006251414.1 regulator of G-protein signaling 12 isoform X1

See identical proteins and their annotated locations for XP_006251414.1

UniProtKB/Swiss-Prot

O08774, O88383

UniProtKB/TrEMBL

D4AB55

Related

ENSRNOP00000045065.4

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:1188 → 1209

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd00992
Location:19 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1387

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_006251353.5 → XP_006251415.1 regulator of G-protein signaling 12 isoform X1

See identical proteins and their annotated locations for XP_006251415.1

UniProtKB/Swiss-Prot

O08774, O88383

UniProtKB/TrEMBL

D4AB55

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:1188 → 1209

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd00992
Location:19 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1387

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_008770350.4 → XP_008768572.1 regulator of G-protein signaling 12 isoform X1

See identical proteins and their annotated locations for XP_008768572.1

UniProtKB/Swiss-Prot

O08774, O88383

UniProtKB/TrEMBL

D4AB55

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:1188 → 1209

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd00992
Location:19 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1387

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_008770351.4 → XP_008768573.1 regulator of G-protein signaling 12 isoform X6

UniProtKB/TrEMBL

A0A0G2K326, A6IK13

Conserved Domains (7) summary

smart00455
Location:387 → 456

RBD; Raf-like Ras-binding domain

cd01817
Location:315 → 387

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08742
Location:68 → 182

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

pfam02188
Location:540 → 561

GoLoco; GoLoco motif

pfam16611
Location:458 → 528

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:617 → 736

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:188 → 285

RGS12_us1; Unstructured region of RGS12
XM_039092340.2 → XP_038948268.1 regulator of G-protein signaling 12 isoform X4

UniProtKB/TrEMBL

A0A8I6GAJ3

Conserved Domains (7) summary

cd08742
Location:95 → 209

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:567 → 588

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd17136
Location:341 → 410

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:485 → 559

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:617 → 766

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:215 → 328

RGS12_us1; Unstructured region of RGS12

cl28922
Location:411 → 483

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_063273512.1 → XP_063129582.1 regulator of G-protein signaling 12 isoform X7
XM_017599342.3 → XP_017454831.1 regulator of G-protein signaling 12 isoform X5

UniProtKB/TrEMBL

A0A8I6GAJ3
XM_039092338.2 → XP_038948266.1 regulator of G-protein signaling 12 isoform X2

UniProtKB/Swiss-Prot

O08774, O88383

Conserved Domains (9) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

smart00390
Location:1188 → 1209

GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

cd00992
Location:19 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1238 → 1382

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
XM_039092339.2 → XP_038948267.1 regulator of G-protein signaling 12 isoform X3

UniProtKB/Swiss-Prot

O08774, O88383

Conserved Domains (7) summary

cd08742
Location:716 → 830

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:19 → 94

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:227 → 358

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

cd17136
Location:962 → 1031

RBD1_RGS12; Ras-binding domain (RBD) 1 of regulator of G protein signaling 12 (RGS12)

pfam16611
Location:1106 → 1137

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16613
Location:836 → 949

RGS12_us1; Unstructured region of RGS12

cl28922
Location:1032 → 1104

Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold