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    Meaf6 MYST/Esa1-associated factor 6 [ Mus musculus (house mouse) ]

    Gene ID: 70088, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Meaf6provided by MGI
    Official Full Name
    MYST/Esa1-associated factor 6provided by MGI
    Primary source
    MGI:MGI:1917338
    See related
    Ensembl:ENSMUSG00000028863 AllianceGenome:MGI:1917338
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310005N01Rik; 2810036M01Rik
    Summary
    Predicted to be involved in histone acetylation. Predicted to act upstream of or within chromatin organization. Predicted to be located in kinetochore. Predicted to be part of histone acetyltransferase complex. Predicted to be active in nucleolus. Orthologous to human MEAF6 (MYST/Esa1 associated factor 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 18.5), whole brain E14.5 (RPKM 16.0) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    4 D2.2; 4 58.03 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124978883..125007031)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125085113..125113238)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6215 Neighboring gene Smad nuclear interacting protein 1 Neighboring gene splicing factor 3a, subunit 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_11351 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:124802021-124802130 Neighboring gene STARR-positive B cell enhancer ABC_E4666 Neighboring gene STARR-positive B cell enhancer ABC_E10258 Neighboring gene zinc finger CCCH type containing 12A Neighboring gene STARR-seq mESC enhancer starr_11354 Neighboring gene STARR-seq mESC enhancer starr_11355 Neighboring gene predicted gene, 40246 Neighboring gene predicted gene, 32611

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes. Matsuura K, et al. Exp Cell Res, 2020 Nov 1. PMID 32918898
    2. Hdac6 regulates Tip60-p400 function in stem cells. Chen PB, et al. Elife, 2013 Dec 3. PMID 24302573, Free PMC Article
    3. The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation. Jacquet K, et al. Mol Cell, 2016 May 5. PMID 27153538, Free PMC Article
    4. Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans. Doyon Y, et al. Mol Cell Biol, 2004 Mar. PMID 14966270, Free PMC Article
    5. ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation. Doyon Y, et al. Mol Cell, 2006 Jan 6. PMID 16387653

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
      Title: MEAF6 is essential for cell proliferation and plays a role in the assembly of KAT7 complexes.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K12 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K5 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to histone H4K8 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of developmental process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of double-strand break repair NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NuA4 histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nucleosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    chromatin modification-related protein MEAF6
    Names
    esa1-associated factor 6 homolog
    protein EAF6 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290701.2 → NP_001277630.1  chromatin modification-related protein MEAF6 isoform 2

      See identical proteins and their annotated locations for NP_001277630.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in 3' coding region and uses an alternate splice site in the 3' terminal exon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK009177, AK012867, AL626775, AW123768, BY133395, BY600332
      Consensus CDS
      CCDS71467.1
      UniProtKB/Swiss-Prot
      B1ASC6, Q2VPQ9, Q9D7J5
      UniProtKB/TrEMBL
      V9GX42
      Related
      ENSMUSP00000122288.2, ENSMUST00000154689.8
      Conserved Domains (1) summary
      pfam09340
      Location:18 → 96
      NuA4; Histone acetyltransferase subunit NuA4

    2. NM_001374123.1 → NP_001361052.1  chromatin modification-related protein MEAF6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK012867, AL626775, BQ178199, CO428776
      UniProtKB/TrEMBL
      B1ASC8
      Related
      ENSMUSP00000101777.4, ENSMUST00000106171.9
      Conserved Domains (1) summary
      pfam09340
      Location:18 → 96
      NuA4; Histone acetyltransferase subunit NuA4

    3. NM_027310.5 → NP_081586.1  chromatin modification-related protein MEAF6 isoform 1

      See identical proteins and their annotated locations for NP_081586.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK009177, AK012867, AL626775, AW123768, BY133395, BY600332
      Consensus CDS
      CCDS18637.1
      UniProtKB/TrEMBL
      V9GX42
      Related
      ENSMUSP00000053543.5, ENSMUST00000055213.11
      Conserved Domains (1) summary
      pfam09340
      Location:18 → 96
      NuA4; Histone acetyltransferase subunit NuA4

    RNA

    1. NR_151472.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK012867, AL626775, AW123768, BY133395, BY600332, CX220687

    2. NR_164336.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK012867, AL626775, BQ178199, CD353468

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      124978883..125007031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003955011.2 RNA Sequence

    2. XR_003955012.2 RNA Sequence

    3. XR_004941956.1 RNA Sequence

    4. XR_003955014.2 RNA Sequence

    5. XR_003955013.2 RNA Sequence

    6. XR_004941957.1 RNA Sequence

    7. XR_004941958.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2VPQ9.1 GenPept UniProtKB/Swiss-Prot:Q2VPQ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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