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    Tmx3 thioredoxin-related transmembrane protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 67988, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tmx3provided by MGI
    Official Full Name
    thioredoxin-related transmembrane protein 3provided by MGI
    Primary source
    MGI:MGI:2442418
    See related
    Ensembl:ENSMUSG00000024614 AllianceGenome:MGI:2442418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Txndc10; mKIAA1830; 6430411B10Rik; A730024F05Rik
    Summary
    Predicted to enable protein disulfide isomerase activity and protein-disulfide reductase activity. Predicted to be involved in peptidyl-cysteine oxidation. Located in cell surface. Is expressed in embryo; eye; lens epithelium; retina; and retina outer nuclear layer. Orthologous to human TMX3 (thioredoxin related transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 8.1), cerebellum adult (RPKM 7.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    18 E4; 18 59.37 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (90528336..90561391)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (90510154..90543267)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene TNF receptor-associated factor 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_45306 Neighboring gene predicted gene, 18280 Neighboring gene STARR-seq mESC enhancer starr_45307 Neighboring gene STARR-positive B cell enhancer ABC_E7622 Neighboring gene predicted gene, 25418 Neighboring gene STARR-seq mESC enhancer starr_45308 Neighboring gene STARR-seq mESC enhancer starr_45309 Neighboring gene predicted gene 45871

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nt mutation causing laterality defects associated with deletion of rotatin. Chatterjee B, et al. Mamm Genome, 2007 May. PMID 17551791
    2. A male with unilateral microphthalmia reveals a role for TMX3 in eye development. Chao R, et al. PLoS One, 2010 May 11. PMID 20485507, Free PMC Article
    3. Platelets release novel thiol isomerase enzymes which are recruited to the cell surface following activation. Holbrook LM, et al. Br J Haematol, 2010 Feb. PMID 19995400
    4. Deletion of Lrp4 increases the incidence of microphthalmia. Tanahashi H, et al. Biochem Biophys Res Commun, 2018 Nov 30. PMID 30352686
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein disulfide isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-disulfide reductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein disulfide-isomerase TMX3
    Names
    thioredoxin domain containing 10
    thioredoxin domain-containing protein 10
    NP_938037.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198295.3 → NP_938037.2  protein disulfide-isomerase TMX3 precursor

      See identical proteins and their annotated locations for NP_938037.2

      Status: VALIDATED

      Source sequence(s)
      AC163277
      Consensus CDS
      CCDS37879.1
      UniProtKB/Swiss-Prot
      Q3US84, Q6PGA1, Q6ZPH5, Q8BXZ1, Q8BZB8
      Related
      ENSMUSP00000025515.7, ENSMUST00000025515.7
      Conserved Domains (3) summary
      cd03000
      Location:30 → 133
      PDI_a_TMX3; PDIa family, TMX3 subfamily; composed of eukaryotic proteins similar to human TMX3, a TRX related transmembrane protein containing one redox active TRX domain at the N-terminus and a classical ER retrieval sequence for type I transmembrane proteins at ...
      pfam13848
      Location:163 → 340
      Thioredoxin_6; Thioredoxin-like domain
      cl00388
      Location:260 → 343
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      90528336..90561391
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BXZ1.2 GenPept UniProtKB/Swiss-Prot:Q8BXZ1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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