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    PCYOX1L prenylcysteine oxidase 1 like [ Homo sapiens (human) ]

    Gene ID: 78991, updated on 5-Mar-2024

    Summary

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    Official Symbol
    PCYOX1Lprovided by HGNC
    Official Full Name
    prenylcysteine oxidase 1 likeprovided by HGNC
    Primary source
    HGNC:HGNC:28477
    See related
    Ensembl:ENSG00000145882 AllianceGenome:HGNC:28477
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Predicted to enable prenylcysteine oxidase activity. Predicted to be involved in prenylated protein catabolic process. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 5.8), brain (RPKM 5.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PCYOX1L in Genome Data Viewer
    Location:
    5q32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (149358046..149369653)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (149892861..149904468)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (148737609..148749216)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene actin filament associated protein 1 like 1 Neighboring gene uncharacterized LOC124901103 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:148724745-148725370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:148725371-148725994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148726519-148727019 Neighboring gene GRPEL2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10017 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16496 Neighboring gene GrpE like 2, mitochondrial Neighboring gene Sharpr-MPRA regulatory region 12528 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148746417-148747281 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148747282-148748145 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148759103-148759637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148759990-148760702 Neighboring gene uncharacterized LOC101927046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148762129-148762840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148764726-148765226 Neighboring gene interleukin 17B Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82075 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148784456-148785046 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:148786897-148787897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148790014-148790554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:148790555-148791094 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82102 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_82107 Neighboring gene VISTA enhancer hs1752 Neighboring gene cardiac mesoderm enhancer-associated non-coding RNA Neighboring gene microRNA 143

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities. Petenkova A, et al. Nat Commun, 2023 May 13. PMID 37179332, Free PMC Article
    2. TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination. Wang G, et al. Ann Rheum Dis, 2020 Aug. PMID 32409323, Free PMC Article
    3. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Wong CK, et al. Mol Cancer Res, 2020 Mar. PMID 31932471, Free PMC Article
    4. Discovery of a Human Testis-specific Protein Complex TEX101-DPEP3 and Selection of Its Disrupting Antibodies. Schiza C, et al. Mol Cell Proteomics, 2018 Dec. PMID 30097533, Free PMC Article
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. Zhang Z, et al. Protein Sci, 2004 Oct. PMID 15340161, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC3265

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables prenylcysteine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in prenylated protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prenylcysteine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    located_in platelet alpha granule lumen TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    prenylcysteine oxidase-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301054.2 → NP_001287983.1  prenylcysteine oxidase-like isoform 2

      See identical proteins and their annotated locations for NP_001287983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. It has an alternate splice site in the 5' region, which results in an alternate translation initiation site, compared to variant 1. The resulting isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF451985, AK090410, DA368718, DB573610
      UniProtKB/TrEMBL
      E7EVZ5
      Related
      ENSP00000428512.1, ENST00000514349.1
      Conserved Domains (2) summary
      pfam07156
      Location:105 → 466
      Prenylcys_lyase; Prenylcysteine lyase
      pfam13450
      Location:14 → 79
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    2. NM_001301057.2 → NP_001287986.1  prenylcysteine oxidase-like isoform 3

      See identical proteins and their annotated locations for NP_001287986.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate splice site in the 5' region, which results in an alternate translation initiation site, and has an alternate in-frame splice site in the central region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform 1.
      Source sequence(s)
      AK090410, BC000014, DA368718, DB573610
      UniProtKB/TrEMBL
      E7EVZ5
      Conserved Domains (2) summary
      pfam07156
      Location:105 → 407
      Prenylcys_lyase; Prenylcysteine lyase
      pfam13450
      Location:14 → 79
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    3. NM_024028.4 → NP_076933.3  prenylcysteine oxidase-like isoform 1 precursor

      See identical proteins and their annotated locations for NP_076933.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK075414, BP397957, DA368718
      Consensus CDS
      CCDS4296.1
      UniProtKB/Swiss-Prot
      Q7Z4S2, Q8NBM8, Q8NCY5, Q8NF69, Q9BTE8, Q9BWS3
      UniProtKB/TrEMBL
      E7EVZ5
      Related
      ENSP00000274569.4, ENST00000274569.9
      Conserved Domains (2) summary
      pfam07156
      Location:122 → 483
      Prenylcys_lyase; Prenylcysteine lyase
      pfam13450
      Location:31 → 96
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      149358046..149369653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      149892861..149904468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NBM8.2 GenPept UniProtKB/Swiss-Prot:Q8NBM8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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