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    LERFS lncRNA negative regulator of fibroblast-like synoviocyte migration, SYNCRIP interacting [ Homo sapiens (human) ]

    Gene ID: 403323, updated on 10-Oct-2023

    Summary

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    Official Symbol
    LERFSprovided by HGNC
    Official Full Name
    lncRNA negative regulator of fibroblast-like synoviocyte migration, SYNCRIP interactingprovided by HGNC
    Primary source
    HGNC:HGNC:51182
    See related
    AllianceGenome:HGNC:51182
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Ubiquitous expression in testis (RPKM 2.4), thyroid (RPKM 2.1) and 25 other tissues See more
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    Genomic context

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    Location:
    9q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (62857856..62898087, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (80284687..80324093)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (66513680..66553911, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene PTGER4P2-CDK2AP2P2 readthrough, transcribed pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:66500322-66500855 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66508451-66508950 Neighboring gene cyclin dependent kinase 2 associated protein 2 pseudogene 2 Neighboring gene prostaglandin E receptor 4 pseudogene 2 Neighboring gene myosin VB pseudogene 2 Neighboring gene adhesion G protein-coupled receptor F5 pseudogene 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:66530343-66531053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28435 Neighboring gene fibroblast growth factor 7 pseudogene 8 Neighboring gene family with sequence similarity 88 member B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66570705-66571492 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66571493-66572278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66581406-66581906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:66581907-66582407 Neighboring gene CNTNAP3 pseudogene 1 Neighboring gene coiled-coil domain-containing protein 86-like Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr9:66950247-66950746

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation. Zou Y, et al. J Clin Invest, 2018 Oct 1. PMID 30198906, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • lowly expressed in rheumatoid fibroblast-like synoviocytes

    Clone Names

    • FLJ97721, FLJ99937

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_122076.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript.
      Source sequence(s)
      AL512625

    2. NR_122077.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate splice site in the 5' terminal exon, lacks multiple 3' exons, and contains an alternate 3' terminal exon, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AK000451

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      62857856..62898087 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      80284687..80324093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_203449.1: Suppressed sequence

      Description
      NM_203449.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.