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    PCAT7 prostate cancer associated transcript 7 [ Homo sapiens (human) ]

    Gene ID: 101928099, updated on 26-Oct-2023

    Summary

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    Official Symbol
    PCAT7provided by HGNC
    Official Full Name
    prostate cancer associated transcript 7provided by HGNC
    Primary source
    HGNC:HGNC:48824
    See related
    Ensembl:ENSG00000231806 AllianceGenome:HGNC:48824
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCAN-R2
    Expression
    Biased expression in stomach (RPKM 5.4), testis (RPKM 2.0) and 9 other tissues See more
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    Genomic context

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    Location:
    9q22.32
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (94554599..94574654)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (106723923..106743981)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (97317327..97331038)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily domain containing 14B Neighboring gene yrdC N(6)-threonylcarbamoyltransferase domain containing pseudogene 1 Neighboring gene MPRA-validated peak7296 silencer Neighboring gene uncharacterized LOC107987100 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110230 Neighboring gene MPRA-validated peak7297 silencer Neighboring gene leishmanolysin like peptidase pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110244 Neighboring gene RNA, U6 small nuclear 669, pseudogene Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110264 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110288 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_110294 Neighboring gene uncharacterized LOC124902218 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97315577-97316239 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97316904-97317566 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97320892-97321392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97349793-97350294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97350295-97350794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:97353573-97354115 Neighboring gene fructose-bisphosphatase 2 Neighboring gene NANOG hESC enhancer GRCh37_chr9:97370327-97370828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:97372257-97372756 Neighboring gene fructose-bisphosphatase 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28632 Neighboring gene Sharpr-MPRA regulatory region 4124 Neighboring gene uncharacterized LOC124902219 Neighboring gene uncharacterized LOC107987101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA PCAT7 promotes the malignant progression of breast cancer by regulating ErbB/PI3K/Akt pathway. Zhou J, et al. Future Oncol, 2021 Feb. PMID 33401925
    2. LncRNA PCAT6 promotes the proliferation, migration and invasion of pancreatic ductal adenocarcinoma via regulating miR-185-5p/CBX2 axis. Wang W, et al. Pathol Res Pract, 2020 Sep. PMID 32825947
    3. Long Non-Coding RNA Prostate Cancer-Associated Transcript 7 (PCAT7) Induces Poor Prognosis and Promotes Tumorigenesis by Inhibiting mir-134-5p in Non-Small-Cell Lung (NSCLC). Liu Q, et al. Med Sci Monit, 2017 Dec 24. PMID 29275424, Free PMC Article
    4. Integrative genomic analyses reveal clinically relevant long noncoding RNAs in human cancer. Du Z, et al. Nat Struct Mol Biol, 2013 Jul. PMID 23728290, Free PMC Article
    5. SMAD3/SP1 complex-mediated constitutive active loop between lncRNA PCAT7 and TGF-β signaling promotes prostate cancer bone metastasis. Lang C, et al. Mol Oncol, 2020 Apr. PMID 31925912, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA PCAT7 promotes the malignant progression of breast cancer by regulating ErbB/PI3K/Akt pathway.
      Title: LncRNA PCAT7 promotes the malignant progression of breast cancer by regulating ErbB/PI3K/Akt pathway.
    2. LncRNA PCAT6 promotes the proliferation, migration and invasion of pancreatic ductal adenocarcinoma via regulating miR-185-5p/CBX2 axis.
      Title: LncRNA PCAT6 promotes the proliferation, migration and invasion of pancreatic ductal adenocarcinoma via regulating miR-185-5p/CBX2 axis.
    3. SMAD3/SP1 complex-mediated constitutive active loop between lncRNA PCAT7 and TGF-beta signaling promotes prostate cancer bone metastasis.
      Title: SMAD3/SP1 complex-mediated constitutive active loop between lncRNA PCAT7 and TGF-β signaling promotes prostate cancer bone metastasis.
    4. Overexpression of PCAT7 resulted in the promotion of tumor cell proliferation, inhibition of cells apoptosis, facilitation of cells metastasis, and formation of EMT phenotype, while PCAT7 expression deletion remarkably prohibited cell proliferation, accelerated their apoptosis, weakened metastasis, and reversed EMT to MET.
      Title: Long Non-Coding RNA Prostate Cancer-Associated Transcript 7 (PCAT7) Induces Poor Prognosis and Promotes Tumorigenesis by Inhibiting mir-134-5p in Non-Small-Cell Lung (NSCLC).
    5. PCAT7 contributed to the progression of nasopharyngeal carcinoma through regulating miR-134-5p/ELF2 signaling pathway.
      Title: Long non-coding RNA PCAT7 regulates ELF2 signaling through inhibition of miR-134-5p in nasopharyngeal carcinoma.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Other Names

    • prostate cancer associated transcript 7 (non-protein coding)
    • prostate cancer-associated noncoding RNA 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_121566.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    2. NR_121567.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728
      Related
      ENST00000644721.1

    3. NR_121568.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    4. NR_121569.3 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    5. NR_185898.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    6. NR_185899.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    7. NR_185900.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    8. NR_185901.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    9. NR_185902.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    10. NR_185903.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    11. NR_185904.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    12. NR_185905.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    13. NR_185906.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    14. NR_185907.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL161728

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      94554599..94574654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      106723923..106743981
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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