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    Supv3l1 suppressor of var1, 3-like 1 (S. cerevisiae) [ Mus musculus (house mouse) ]

    Gene ID: 338359, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Supv3l1provided by MGI
    Official Full Name
    suppressor of var1, 3-like 1 (S. cerevisiae)provided by MGI
    Primary source
    MGI:MGI:2441711
    See related
    Ensembl:ENSMUSG00000020079 AllianceGenome:MGI:2441711
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330443E10Rik
    Summary
    Predicted to enable helicase activity; nucleic acid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including mitochondrial RNA metabolic process; mitochondrion morphogenesis; and positive regulation of mitochondrial RNA catabolic process. Located in mitochondrion. Is expressed in several structures, including brain; early embryo; extraembryonic component; sensory organ; and skin. Orthologous to human SUPV3L1 (Suv3 like RNA helicase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 5.0), CNS E11.5 (RPKM 4.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B4; 10 32.4 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62265000..62287294, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62429221..62451515, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hexokinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E9791 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61803279-61803470 Neighboring gene hexokinase 1, opposite strand Neighboring gene hexokinase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_26882 Neighboring gene predicted gene, 30322 Neighboring gene RIKEN cDNA 4930507D05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912425-61912612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912686-61912869 Neighboring gene VPS26 retromer complex component A Neighboring gene STARR-seq mESC enhancer starr_26885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61949721-61949830 Neighboring gene STARR-seq mESC enhancer starr_26886 Neighboring gene STARR-positive B cell enhancer ABC_E6862 Neighboring gene STARR-positive B cell enhancer ABC_E6863 Neighboring gene STARR-positive B cell enhancer ABC_E6864 Neighboring gene serglycin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan. Chen PL, et al. Oncogene, 2013 Feb 28. PMID 22562243, Free PMC Article
    2. Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse. Paul E, et al. Transgenic Res, 2010 Aug. PMID 19937380, Free PMC Article
    3. Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death. Paul E, et al. Mamm Genome, 2009 Feb. PMID 19145458, Free PMC Article
    4. Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality. Pereira M, et al. Mech Ageing Dev, 2007 Nov-Dec. PMID 17961633
    5. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Fisher CL, et al. Nucleic Acids Res, 2017 Dec 1. PMID 28981838, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUV3 Helicase and Mitochondrial Homeostasis.
      Title: SUV3 Helicase and Mitochondrial Homeostasis.
    2. Spatial and temporal aspects of Supv3L1 promoter activity.
      Title: Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse.
    3. Supv3L1 is important for the maintenance of the skin barrier. In addition, loss of Supv3L1 function leads to accelerated aging-like phenotypes.
      Title: Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.
    4. Mice homozygous for Supv3L1 mutation die in utero before midgestation.
      Title: Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (9)  1 citation
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on acid anhydrides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA duplex unwinding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial RNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial RNA surveillance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial mRNA surveillance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial ncRNA surveillance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of mitochondrial RNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial degradosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial degradosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ATP-dependent RNA helicase SUPV3L1, mitochondrial
    Names
    SUV3-like protein 1
    suppressor of var1 3-like protein 1
    NP_001346735.1
    NP_852088.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359806.1 → NP_001346735.1  ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK031911, AK143755, AW049139, BB859685
      Conserved Domains (2) summary
      cd00079
      Location:112 → 247
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam12513
      Location:387 → 433
      SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

    2. NM_181423.3 → NP_852088.1  ATP-dependent RNA helicase SUPV3L1, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_852088.1

      Status: VALIDATED

      Source sequence(s)
      AK143755, AW049139, BB859685, BC049796
      Consensus CDS
      CCDS35920.1
      UniProtKB/Swiss-Prot
      Q50HX5, Q80YD1
      Related
      ENSMUSP00000020273.10, ENSMUST00000020273.16
      Conserved Domains (3) summary
      smart00487
      Location:187 → 353
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:351 → 486
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      pfam12513
      Location:626 → 672
      SUV3_C; Mitochondrial degradasome RNA helicase subunit C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62265000..62287294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003948720.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YD1.1 GenPept UniProtKB/Swiss-Prot:Q80YD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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