Comtd1 catechol-O-methyltransferase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Comtd1provided by RGD
Official Full Name: catechol-O-methyltransferase domain containing 1provided by RGD
Primary source: RGD:1306581
See related: Ensembl:ENSRNOG00000013968 AllianceGenome:RGD:1306581
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable S-adenosylmethionine-dependent methyltransferase activity. Predicted to be involved in methylation. Predicted to be integral component of membrane. Orthologous to human COMTD1 (catechol-O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 62.5), Kidney (RPKM 47.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p16

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (2509121..2512232)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (2459783..2462895)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (2631529..2634640)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH142258 (e-PCR)
- UniSTS:231505

RH141113 (e-PCR)
- UniSTS:223109

RH135028 (e-PCR)
- UniSTS:218305

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables O-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-adenosylmethionine-dependent methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: catechol O-methyltransferase domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107249.1 → NP_001100719.1 catechol O-methyltransferase domain-containing protein 1

See identical proteins and their annotated locations for NP_001100719.1

Status: PROVISIONAL

Source sequence(s)

CH474061

UniProtKB/TrEMBL

A6KKT5, D3ZM21

Related

ENSRNOP00000018897.4, ENSRNOT00000018897.6

Conserved Domains (2) summary

COG4122
Location:54 → 261

YrrM; Predicted O-methyltransferase YrrM [General function prediction only]

cl17173
Location:60 → 261

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...