MFGE8 milk fat globule EGF and factor V/VIII domain containing [Bos taurus (cattle)] - Gene

Summary

Official Symbol: MFGE8provided by VGNC
Official Full Name: milk fat globule EGF and factor V/VIII domain containingprovided by VGNC
Primary source: VGNC:VGNC:31426
See related: BGD:BT11041; Ensembl:ENSBTAG00000003300
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 21

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	21	NC_037348.1 (20467445..20482504, complement)

Chromosome 21 - NC_037348.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037348.1 Chromosome 21 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The vesicular environment provides optimal conditions for presentation and recognition of phosphatidylserine by lactadherin in a simple binding mechanism.
Title: Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition.
lactophorin C-terminal fragment (LP16) and bovine milk fat globule membrane protein PAS6/7 strongly inhibited the replication of human rotavirus replication
Title: The bovine lactophorin C-terminal fragment and PAS6/7 were both potent in the inhibition of human rotavirus replication in cultured epithelial cells and the prevention of experimental gastroenteritis.
angiogenic endothelial cells have phagocytic properties for lactadherin-opsonized large particles and apoptotic cells
Title: Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells.
analysis of membrane-interactive loops of Lact-C2
Title: Crystal structure of lactadherin C2 domain at 1.7A resolution with mutational and computational analyses of its membrane-binding motif.
The crystal structure of the bovine lactadherin C2 domain (residues 1 to 158) at 2.4 A, was determined.
Title: Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII.
Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites.
Title: Lactadherin inhibits enzyme complexes of blood coagulation by competing for phospholipid-binding sites.
The number of lactadherin binding sites increased proportionally to the phosphatidylserine content over a range 0-2% and less rapidly for higher phosphatidylserine content
Title: Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature.

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General gene information

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Markers

MFGE8 (e-PCR)
- UniSTS:519318

MFGE8 (e-PCR)
- UniSTS:278738

General protein information

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Preferred Names: lactadherin

Names: BP47; MFG-E8; MFGM; MGP57/53; PAS-6/PAS-7 glycoprotein; SED1; components 15/16; milk fat globule-EGF factor 8 protein; sperm surface protein SP47

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_176610.1 → NP_788783.1 lactadherin precursor

See identical proteins and their annotated locations for NP_788783.1

Status: PROVISIONAL

Source sequence(s)

X91895

UniProtKB/Swiss-Prot

P79344, Q27959, Q95114

Related

ENSBTAP00000004272.3, ENSBTAT00000004272.5

Conserved Domains (4) summary

smart00231
Location:269 → 427

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain

cd00054
Location:68 → 106

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:272 → 426

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:24 → 55

EGF; EGF-like domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

NC_037348.1 Reference ARS-UCD2.0 Primary Assembly

Range

20467445..20482504 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024981610.2 → XP_024837378.1 lactadherin isoform X1

UniProtKB/TrEMBL

G3MYW7, Q3T0K7

Conserved Domains (4) summary

cd00054
Location:72 → 110

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00057
Location:224 → 378

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00008
Location:28 → 59

EGF; EGF-like domain

cl25480
Location:115 → 216

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.