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    Foxred1 FAD-dependent oxidoreductase domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 235169, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Foxred1provided by MGI
    Official Full Name
    FAD-dependent oxidoreductase domain containing 1provided by MGI
    Primary source
    MGI:MGI:2446262
    See related
    Ensembl:ENSMUSG00000039048 AllianceGenome:MGI:2446262
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tex23; TEG-23
    Summary
    Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 19. Orthologous to human FOXRED1 (FAD dependent oxidoreductase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in heart adult (RPKM 17.5), subcutaneous fat pad adult (RPKM 11.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    9 A4; 9 20.08 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (35115504..35122499, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (35204208..35211171, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene decapping enzyme, scavenger Neighboring gene predicted gene, 24262 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:34983517-34983704 Neighboring gene STARR-positive B cell enhancer ABC_E6723 Neighboring gene toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Neighboring gene predicted gene, 39318 Neighboring gene STARR-positive B cell enhancer ABC_E5059 Neighboring gene STARR-seq mESC enhancer starr_23764 Neighboring gene STARR-seq mESC enhancer starr_23765 Neighboring gene signal recognition particle receptor alpha Neighboring gene family with sequence similarity 118, member B Neighboring gene STARR-positive B cell enhancer ABC_E3823 Neighboring gene RNA pseudouridylate synthase domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Tex261, a novel gene presumably related but distinct from steroidogenic acute regulatory (StAR) gene, is regulated during the development of germ cells. López-Fernández LA, et al. Biochem Biophys Res Commun, 1998 Jan 26. PMID 9464256
    2. Characterization of genes expressed early in mouse spermatogenesis, isolated from a subtractive cDNA library. López-Fernández LA, et al. Mamm Genome, 1996 Sep. PMID 8703127
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38853

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex I assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial respiratory chain complex I ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in respirasome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FAD-dependent oxidoreductase domain-containing protein 1
    Names
    testis expressed gene 23

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291448.2 → NP_001278377.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001278377.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 2.
      Source sequence(s)
      AC140448
      Consensus CDS
      CCDS80974.1
      UniProtKB/Swiss-Prot
      Q3TQB2, Q8R1D0
      Related
      ENSMUSP00000118037.2, ENSMUST00000127996.8
      Conserved Domains (2) summary
      COG0665
      Location:60 → 479
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      cl21454
      Location:65 → 98
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. NM_001291449.2 → NP_001278378.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice near its 5' end that results in translation initiation at a downstream AUG compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC140448
      Conserved Domains (1) summary
      COG0665
      Location:3 → 302
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    3. NM_001359815.2 → NP_001346744.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice near its 5' end that results in translation initiation at a downstream AUG compared to variant 1. The resulting protein (isoform 3) is shorter and has a distinct N-terminus compared to isoform 1. Variants 3 and 4 encode the same protein.
      Source sequence(s)
      AC140448
      Conserved Domains (1) summary
      COG0665
      Location:3 → 302
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    4. NM_001421609.1 → NP_001408538.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140448

    5. NM_001421610.1 → NP_001408539.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140448

    6. NM_172291.3 → NP_758495.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_758495.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AC140448
      Consensus CDS
      CCDS22958.1
      UniProtKB/Swiss-Prot
      Q3TQB2
      Related
      ENSMUSP00000038924.9, ENSMUST00000043805.15
      Conserved Domains (2) summary
      COG0665
      Location:60 → 485
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]
      cl21454
      Location:65 → 98
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. NR_185317.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC140448

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      35115504..35122499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244290.2 → XP_030100150.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

      Conserved Domains (1) summary
      COG0665
      Location:1 → 291
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    2. XM_011242483.4 → XP_011240785.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      See identical proteins and their annotated locations for XP_011240785.1

      Conserved Domains (1) summary
      COG0665
      Location:3 → 308
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    3. XM_017313309.3 → XP_017168798.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      COG0665
      Location:60 → 404
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    4. XM_006510223.5 → XP_006510286.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X1

      Conserved Domains (1) summary
      COG0665
      Location:60 → 410
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    5. XM_030244288.2 → XP_030100148.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

      Conserved Domains (1) summary
      COG0665
      Location:1 → 291
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    6. XM_006510226.5 → XP_006510289.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X5

      Conserved Domains (1) summary
      COG0665
      Location:1 → 297
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    7. XM_036154879.1 → XP_036010772.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

      Related
      ENSMUST00000130072.8
      Conserved Domains (1) summary
      COG0665
      Location:1 → 291
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    8. XM_030244291.2 → XP_030100151.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

      Conserved Domains (1) summary
      COG0665
      Location:1 → 291
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    9. XM_036154873.1 → XP_036010766.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      COG0665
      Location:3 → 308
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    10. XM_036154874.1 → XP_036010767.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      COG0665
      Location:3 → 308
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    11. XM_030244289.2 → XP_030100149.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X6

      Conserved Domains (1) summary
      COG0665
      Location:1 → 291
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    12. XM_006510224.5 → XP_006510287.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      See identical proteins and their annotated locations for XP_006510287.1

      Conserved Domains (1) summary
      COG0665
      Location:3 → 308
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    13. XM_036154875.1 → XP_036010768.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X4

      Conserved Domains (1) summary
      COG0665
      Location:3 → 302
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    14. XM_036154872.1 → XP_036010765.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      COG0665
      Location:3 → 308
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    15. XM_036154877.1 → XP_036010770.1  FAD-dependent oxidoreductase domain-containing protein 1 isoform X5

      Related
      ENSMUST00000143039.8
      Conserved Domains (1) summary
      COG0665
      Location:1 → 297
      DadA; Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism]

    RNA

    1. XR_004935399.1 RNA Sequence

    2. XR_004935398.1 RNA Sequence

    3. XR_003947868.2 RNA Sequence

    4. XR_379114.5 RNA Sequence

    5. XR_379113.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TQB2.1 GenPept UniProtKB/Swiss-Prot:Q3TQB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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