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    Rpl38 ribosomal protein L38 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689284, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Rpl38provided by RGD
    Official Full Name
    ribosomal protein L38provided by RGD
    Primary source
    RGD:1305573
    See related
    Ensembl:ENSRNOG00000066047 AllianceGenome:RGD:1305573
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and ribonucleoprotein complex assembly. Predicted to act upstream of or within several processes, including 90S preribosome assembly; middle ear morphogenesis; and sensory perception of sound. Part of cytosolic large ribosomal subunit. Orthologous to human RPL38 (ribosomal protein L38). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 2403.4), Thymus (RPKM 2293.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q32.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (100200414..100204070)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (99701330..99705004)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (103198424..103202059)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480723 Neighboring gene keratin-associated protein 4-5-like Neighboring gene tweety family member 2 Neighboring gene small nucleolar RNA SNORA67 Neighboring gene dynein, axonemal, intermediate chain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Ectopic mineralization in the middle ear and chronic otitis media with effusion caused by RPL38 deficiency in the Tail-short (Ts) mouse. Noben-Trauth K, et al. J Biol Chem, 2011 Jan 28. PMID 21062742, Free PMC Article
    2. The primary structure of rat ribosomal protein L38. Kuwano Y, et al. Biochem Biophys Res Commun, 1991 Mar 15. PMID 1840484
    3. Isolation of eukaryotic ribosomal proteins. Purification and characterization of the 60 S ribosomal subunit proteins La, Lb, Lf, P1, P2, L13', L14, L18', L20, and L38. Tsurugi K, et al. J Biol Chem, 1978 Feb 10. PMID 621213
    4. Characterization of the proteome, diseases and evolution of the human postsynaptic density. Bayés A, et al. Nat Neurosci, 2011 Jan. PMID 21170055, Free PMC Article
    5. Structural snapshots of actively translating human ribosomes. Behrmann E, et al. Cell, 2015 May 7. PMID 25957688, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC125176

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 90S preribosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within axial mesoderm development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within middle ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within ossification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-RNA complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within skeletal system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of cytosolic large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of eukaryotic 80S initiation complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein eL38
    Names
    60S ribosomal protein L38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077592.1 → NP_001071060.1  large ribosomal subunit protein eL38

      See identical proteins and their annotated locations for NP_001071060.1

      Status: PROVISIONAL

      Source sequence(s)
      BC101933
      UniProtKB/Swiss-Prot
      P63174, Q3T1G5
      UniProtKB/TrEMBL
      A6HKI5
      Related
      ENSRNOP00000088903.1, ENSRNOT00000095224.1
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      100200414..100204070
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768393.3 → XP_008766615.1  large ribosomal subunit protein eL38 isoform X1

      See identical proteins and their annotated locations for XP_008766615.1

      UniProtKB/Swiss-Prot
      P63174, Q3T1G5
      UniProtKB/TrEMBL
      A6HKI5
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family

    2. XM_039086868.2 → XP_038942796.1  large ribosomal subunit protein eL38 isoform X1

      UniProtKB/Swiss-Prot
      P63174, Q3T1G5
      UniProtKB/TrEMBL
      A6HKI5
      Conserved Domains (1) summary
      pfam01781
      Location:2 → 68
      Ribosomal_L38e; Ribosomal L38e protein family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63174.2 GenPept UniProtKB/Swiss-Prot:P63174

    Gene LinkOut

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