U.S. flag

An official website of the United States government

GTR Home > Conditions/Phenotypes > Acute lymphoid leukemia

Acute lymphoid leukemia

Synonyms
Acute lymphoblastic leukemia; Acute lymphocytic leukemia; Familial Acute Lymphocytic Leukemia; Leukemia, acute lymphoblastic, somatic; Lymphoblastic leukemia

Summary

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (613067), which has been mapped to chromosome 7p12.2; and ALL3 (615545), which is caused by mutation in the PAX5 gene (167414) on chromosome 9p. [from OMIM]

Available tests

216 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Clinical tests (215 available)

Cytogenetics Tests

Molecular Genetics Tests

Research tests

Genes See tests for all associated and related genes

  • Also known as: BCL2L4, BAX
    Summary: BCL2 associated X, apoptosis regulator

  • Also known as: ALL, BCR1, CML, D22S11, D22S662, PHL, BCR
    Summary: BCR activator of RhoGEF and GTPase

  • Also known as: CD135, FLK-2, FLK2, STK1, FLT3
    Summary: fms related receptor tyrosine kinase 3

  • Also known as: HG2A, MDS, MRD42, GNB1
    Summary: G protein subunit beta 1

  • Also known as: AT-V1, AT-V2, ATV, NBS, NBS1, P95, NBN
    Summary: nibrin

  • Also known as: CAIN, CAN, IIAE9, NUP214
    Summary: nucleoporin 214

  • Also known as: SCL, TCL5, bHLHa17, tal-1, TAL1
    Summary: TAL bHLH transcription factor 1, erythroid differentiation factor

  • Also known as: , TAL2
    Summary: TAL bHLH transcription factor 2

Clinical features

Help
Imported from Human Phenotype Ontology (HPO)

Show allHide all

IMPORTANT NOTE: NIH does not independently verify information submitted to the GTR; it relies on submitters to provide information that is accurate and not misleading. NIH makes no endorsements of tests or laboratories listed in the GTR. GTR is not a substitute for medical advice. Patients and consumers with specific questions about a genetic test should contact a health care provider or a genetics professional.