Carcinoma of colon
- Synonyms
- Colon carcinoma; Colonic carcinoma
Summary
Excerpted from the GeneReview:Lynch syndrome is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, ovary, stomach, small bowel, urinary tract, biliary tract, brain (usually glioblastoma), skin (sebaceous adenomas, sebaceous carcinomas, and keratoacanthomas), pancreas, and prostate. Cancer risks and age of onset vary depending on the associated gene. Several other cancer types have been reported to occur in individuals with Lynch syndrome (e.g., breast, sarcomas, adrenocortical carcinoma). However, the data are not sufficient to demonstrate that the risk of developing these cancers is increased in individuals with Lynch syndrome.
- Full text of GeneReview (by section):
- Summary
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- Chapter Notes
- References
- Authors:
- Gregory Idos
- Laura Valle
- view full author information
Available tests
187 tests are in the database for this condition.
Check Related conditions for additional relevant tests.
Clinical tests (185 available)
Biochemical Genetics Tests
Molecular Genetics Tests
- Deletion/duplication analysis (115)
- Detection of homozygosity (1)
- Methylation analysis (2)
- Microsatellite instability testing (MSI) (5)
- Mutation scanning of select exons (1)
- Sequence analysis of select exons (18)
- RNA analysis (11)
- Targeted variant analysis (28)
- Sequence analysis of the entire coding region (136)
Research tests
- Imperiale et al., 2014Multitarget stool DNA testing for colorectal-cancer screening.
- AMA/NCHPEG, 2012
- NCCN, 2023NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Colon Cancer, 2023
- NICE, 2021UK NICE Guideline NG151, Colorectal cancer, 2021
- AHRQ, 2013Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)
- ACMG ACT, 2012American College of Medical Genetics and Genomics Family History ACT Sheet, Colon Cancer (Asymptomatic), 2012
- NCCN, 2011NCCN Task Force report: Evaluating the clinical utility of tumor markers in oncology.
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