Juvenile primary lateral sclerosis
- Synonyms
- PLS juvenile
- Modes of inheritance
- Autosomal recessive inheritance (Orphanet)
Summary
Excerpted from the GeneReview:- Full text of GeneReview (by section):
- Summary
- GeneReview Scope
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- Chapter Notes
- References
- Authors:
- Richard W Orrell
- view full author information
Available tests
Check Related conditions for additional relevant tests.
Clinical features
Help- Abnormality of head or neck
- Difficulty in tongue movements
Difficulty in tongue movements
- MedGen UID: 377897
- Concept ID: C1853406
- Finding: Finding
Abnormality of head or neck
- Difficulty in tongue movements
- Abnormality of the digestive system
- Dysphagia
Dysphagia
- MedGen UID: 41440
- Concept ID: C0011168
- Finding: Disease or Syndrome
Abnormality of the digestive system
- Dysphagia
- Abnormality of the eye
- Saccadic smooth pursuit
Saccadic smooth pursuit
- MedGen UID: 373096
- Concept ID: C1836479
- Finding: Finding
Abnormality of the eye
- Saccadic smooth pursuit
- Abnormality of the integument
- Pallor
Pallor
- MedGen UID: 10547
- Concept ID: C0030232
- Finding: Finding
Abnormality of the integument
- Pallor
- Abnormality of the nervous system
- Abnormal upper motor neuron morphology
Abnormal upper motor neuron morphology
- MedGen UID: 871241
- Concept ID: C4025723
- Finding: Anatomical Abnormality
Abnormality of the nervous system
- Appendicular spasticity
Appendicular spasticity
- MedGen UID: 937224
- Concept ID: C4313257
- Finding: Finding
Abnormality of the nervous system
- Babinski sign
Babinski sign
- MedGen UID: 19708
- Concept ID: C0034935
- Finding: Finding
Abnormality of the nervous system
- Cerebral cortical atrophy
Cerebral cortical atrophy
- MedGen UID: 1646740
- Concept ID: C4551583
- Finding: Disease or Syndrome
Abnormality of the nervous system
- Decreased compound muscle action potential amplitude
Decreased compound muscle action potential amplitude
- MedGen UID: 908357
- Concept ID: C4230625
- Finding: Finding
Abnormality of the nervous system
- Hyperreflexia
Hyperreflexia
- MedGen UID: 57738
- Concept ID: C0151889
- Finding: Finding
Abnormality of the nervous system
- Loss of ambulation
Loss of ambulation
- MedGen UID: 332305
- Concept ID: C1836843
- Finding: Finding
Abnormality of the nervous system
- Pseudobulbar behavioral symptoms
Pseudobulbar behavioral symptoms
- MedGen UID: 871239
- Concept ID: C4025720
- Finding: Sign or Symptom
Abnormality of the nervous system
- Pseudobulbar paralysis
Pseudobulbar paralysis
- MedGen UID: 10989
- Concept ID: C0033790
- Finding: Disease or Syndrome
Abnormality of the nervous system
- Spastic dysarthria
Spastic dysarthria
- MedGen UID: 105312
- Concept ID: C0454596
- Finding: Finding
Abnormality of the nervous system
- Spastic gait
Spastic gait
- MedGen UID: 115907
- Concept ID: C0231687
- Finding: Finding
Abnormality of the nervous system
- Spastic tetraparesis
Spastic tetraparesis
- MedGen UID: 658719
- Concept ID: C0575059
- Finding: Disease or Syndrome
Abnormality of the nervous system
- Spasticity of facial muscles
Spasticity of facial muscles
- MedGen UID: 344036
- Concept ID: C1853404
- Finding: Finding
Abnormality of the nervous system
- Spasticity of pharyngeal muscles
Spasticity of pharyngeal muscles
- MedGen UID: 342872
- Concept ID: C1853398
- Finding: Finding
Abnormality of the nervous system
- Abnormal upper motor neuron morphology
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