Migraine, familial hemiplegic, 3
Summary
Excerpted from the GeneReview:Familial hemiplegic migraine (FHM) falls within the category of migraine with aura. In migraine with aura (including FHM) the neurologic symptoms of aura are unequivocally localizable to the cerebral cortex or brain stem and include visual disturbance (most common), sensory loss (e.g., numbness or paresthesias of the face or an extremity), and dysphasia (difficulty with speech). FHM must include motor involvement, such as hemiparesis (weakness of an extremity). Hemiparesis occurs with at least one other symptom during FHM aura. Neurologic deficits with FHM attacks can be prolonged for hours to days and may outlast the associated migrainous headache. FHM is often earlier in onset than typical migraine, frequently beginning in the first or second decade; the frequency of attacks tends to decrease with age. Approximately 40%-50% of families with CACNA1A-FHM have cerebellar signs ranging from nystagmus to progressive, usually late-onset mild ataxia.
- Full text of GeneReview (by section):
- Summary
- Diagnosis
- Clinical Characteristics
- Genetically Related (Allelic) Disorders
- Differential Diagnosis
- Management
- Genetic Counseling
- Resources
- Molecular Genetics
- Chapter Notes
- References
- Authors:
- Joanna C Jen
- view full author information
Available tests
79 tests are in the database for this condition.
Check Related conditions for additional relevant tests.
Clinical features
Help- Abnormality of the eye
- Blindness
Blindness
- MedGen UID: 99138
- Concept ID: C0456909
- Finding: Disease or Syndrome
Abnormality of the eye
- Blindness
- Abnormality of the nervous system
- Hemiparesis
Hemiparesis
- MedGen UID: 6783
- Concept ID: C0018989
- Finding: Finding
Abnormality of the nervous system
- Hemiplegia
Hemiplegia
- MedGen UID: 9196
- Concept ID: C0018991
- Finding: Sign or Symptom
Abnormality of the nervous system
- Migraine with aura
Migraine with aura
- MedGen UID: 57822
- Concept ID: C0154723
- Finding: Disease or Syndrome
Abnormality of the nervous system
- Phonophobia
Phonophobia
- MedGen UID: 155864
- Concept ID: C0751466
- Finding: Mental or Behavioral Dysfunction
Abnormality of the nervous system
- Photophobia
Photophobia
- MedGen UID: 43220
- Concept ID: C0085636
- Finding: Sign or Symptom
Abnormality of the nervous system
- Seizure
Seizure
- MedGen UID: 20693
- Concept ID: C0036572
- Finding: Sign or Symptom
Abnormality of the nervous system
- Hemiparesis
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