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GTR Home > Conditions/Phenotypes > Amyotrophic lateral sclerosis type 4


Juvenile amyotrophic lateral sclerosis-4 (ALS4) is an autosomal dominant disorder characterized by distal muscle weakness and atrophy, normal sensation, and pyramidal signs, with onset of symptoms before the age of 25 years, a slow rate of progression, and a normal life span (summary by Chen et al., 2004). For a phenotypic description and a discussion of genetic heterogeneity of amyotrophic lateral sclerosis, see ALS1 (105400). [from OMIM]

Available tests

58 tests are in the database for this condition.

Check Related conditions for additional relevant tests.

Genes See tests for all associated and related genes

  • Also known as: ALS4, AOA2, SCAN2, SCAR1, STEX, Sen1, bA479K20.2, SETX
    Summary: senataxin

Clinical features


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