Oxcarbazepine is the keto-analog of carbamazepine, sharing many therapeutic indications such as epilepsy and other seizure disorders. Like carbamazepine, oxcarbazepine can cause adverse reactions such as Stevens-Johnson syndrome (SJS) and toxic ep. The genetic variant HLA-B*15:02 is associated with the risk of SJS/TEN. Patients who have at least one copy of the HLA-B*15:02 allele (considered HLA-B*15:02-positive) have a significantly increased risk for SJS/TEN compared to non-carriers, and it is recommended that they receive an alternate drug. It is important to note that it is possible for a patient without HLA-B*15:02 to develop SJS/TEN. Guidelines regarding the use of pharmacogenomic tests in dosing for carbamazepine have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and are available on the PharmGKB websites. [from PharmGKB]
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