CDK8 cyclin dependent kinase 8
Gene ID: 1024, updated on 22-Apr-2024Gene type: protein coding
Also known as: K35; IDDHBA
- See all available tests in GTR for this gene
- Go to complete Gene record for CDK8
- Go to Variation Viewer for CDK8 variants
Summary
This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients. GeneReviews: Not available | |
| Intellectual developmental disorder with hypotonia and behavioral abnormalities | not available |
Genomic context
- Location:
- 13q12.13
- Sequence:
- Chromosome: 13; NC_000013.11 (26254129..26405238)
- Total number of exons:
- 15
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for CDK8 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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