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GPNMB glycoprotein nmb

Gene ID: 10457, updated on 25-Nov-2021
Gene type: protein coding
Also known as: NMB; HGFIN; PLCA3


The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Associated conditions

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Amyloidosis, primary localized cutaneous, 3
MedGen: C4554421OMIM: 617920GeneReviews: Not available
See labs
Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease.
GeneReviews: Not available

Genomic context

Chromosome: 7; NC_000007.14 (23246766..23275110)
Total number of exons:


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