MAP3K2 mitogen-activated protein kinase kinase kinase 2
Gene ID: 10746, updated on 5-Mar-2024Gene type: protein coding
Also known as: MEKK2; MEKK2B
- See all available tests in GTR for this gene
- Go to complete Gene record for MAP3K2
- Go to Variation Viewer for MAP3K2 variants
Summary
The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process. [provided by RefSeq, Jul 2008]
Genomic context
- Location:
- 2q14.3
- Sequence:
- Chromosome: 2; NC_000002.12 (127298668..127388465, complement)
- Total number of exons:
- 19
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for MAP3K2 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- Variation ViewerRelated Variants
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