IQGAP2 IQ motif containing GTPase activating protein 2
Gene ID: 10788, updated on 5-Mar-2024Gene type: protein coding
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- Go to complete Gene record for IQGAP2
- Go to Variation Viewer for IQGAP2 variants
Summary
This gene encodes a member of the IQGAP family. The encoded protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. This protein interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. It also acts as a tumor suppressor and has been found to play a role in regulating innate antiviral responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]
Associated conditions
See all available tests in GTR for this gene
Description | Tests |
---|---|
A genome-wide association study for age-related hearing impairment in the Saami. GeneReviews: Not available | |
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. GeneReviews: Not available |
Genomic context
- Location:
- 5q13.3
- Sequence:
- Chromosome: 5; NC_000005.10 (76403285..76708132)
- Total number of exons:
- 41
Variation
Resource | Links for this gene |
---|---|
ClinVar | Variants reported to ClinVar |
dbVar | Studies and variants |
SNP | GeneView ReportGo to Variation Viewer for IQGAP2 variants |
1000 Genomes | See 1000 Genomes Browser (GRCh37.p13) |
- BioSystemsBioSystems
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- SNP: GeneViewSNPs linked from GeneView
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