IRAK3 interleukin 1 receptor associated kinase 3
Gene ID: 11213, updated on 5-Mar-2024Gene type: protein coding
Also known as: ASRT5; IRAKM
- See all available tests in GTR for this gene
- Go to complete Gene record for IRAK3
- Go to Variation Viewer for IRAK3 variants
Summary
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| Asthma-related traits, susceptibility to, 5 | See labs |
| Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. GeneReviews: Not available |
Genomic context
- Location:
- 12q14.3
- Sequence:
- Chromosome: 12; NC_000012.12 (66189214..66254622)
- Total number of exons:
- 12
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for IRAK3 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- IRAK3 database
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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