CHRNA3 cholinergic receptor nicotinic alpha 3 subunit
Gene ID: 1136, updated on 11-Apr-2024Gene type: protein coding
Also known as: LNCR2; PAOD2; BAIPRCK; NACHRA3
- See all available tests in GTR for this gene
- Go to complete Gene record for CHRNA3
- Go to Variation Viewer for CHRNA3 variants
Summary
This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]
Associated conditions
See all available tests in GTR for this gene
| Description | Tests |
|---|---|
| A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. GeneReviews: Not available | |
| A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. GeneReviews: Not available | |
| A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. GeneReviews: Not available | |
| A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. GeneReviews: Not available | |
| A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. GeneReviews: Not available | |
| Beyond cigarettes-per-day: A genome-wide association study of the biomarker carbon monoxide. GeneReviews: Not available | |
| Biological insights from 108 schizophrenia-associated genetic loci. GeneReviews: Not available | |
| Common 5p15.33 and 6p21.33 variants influence lung cancer risk. GeneReviews: Not available | |
| Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. GeneReviews: Not available | |
| Discovery and fine mapping of serum protein loci through transethnic meta-analysis. GeneReviews: Not available | |
| Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer. GeneReviews: Not available | |
| Genetic susceptibility for chronic bronchitis in chronic obstructive pulmonary disease. GeneReviews: Not available | |
| Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. GeneReviews: Not available | |
| Genome-Wide Association Identifies Regulatory Loci Associated with Distinct Local Histogram Emphysema Patterns. GeneReviews: Not available | |
| Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. GeneReviews: Not available | |
| Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. GeneReviews: Not available | |
| Genome-wide meta-analyses identify multiple loci associated with smoking behavior. GeneReviews: Not available | |
| IREB2 and GALC are Associated with Pulmonary Artery Enlargement in Chronic Obstructive Pulmonary Disease. GeneReviews: Not available | |
| Lung cancer susceptibility locus at 5p15.33. GeneReviews: Not available | |
| Meta-analysis and imputation refines the association of 15q25 with smoking quantity. GeneReviews: Not available | |
| Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. GeneReviews: Not available | |
| Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. GeneReviews: Not available | |
| Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. GeneReviews: Not available | |
| Smoking as a quantitative trait locus 3 | See labs |
| Urinary bladder, atony of | See labs |
| Variants in FAM13A are associated with chronic obstructive pulmonary disease. GeneReviews: Not available |
Genomic context
- Location:
- 15q25.1
- Sequence:
- Chromosome: 15; NC_000015.10 (78593052..78620996, complement)
- Total number of exons:
- 9
Variation
| Resource | Links for this gene |
|---|---|
| ClinVar | Variants reported to ClinVar |
| dbVar | Studies and variants |
| SNP | Variation Viewer for CHRNA3 variants |
| Genome viewer | Explore NCBI-annotated and select non-NCBI annotated genome assemblies |
- CHRNA3 database
- ClinVarRelated medical variations
- dbVarLink from Gene to dbVar
- MedGenRelated information in MedGen
- OMIMLink to related OMIM entry
- PubMed (OMIM)Gene links to PubMed derived from omim_pubmed_cited links
- RefSeq RNAsLink to Nucleotide RefSeq RNAs
- RefSeqGeneLink to Nucleotide RefSeqGenes
- Variation ViewerRelated Variants
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